α-Isocyano-p-chlorphenylessigsaeureaethylester

Base Information

• Chemical Name: α-Isocyano-p-chlorphenylessigsaeureaethylester
• CAS No.: 39533-35-2
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.659
• Mol file: 39533-35-2.mol

Synonyms:α-Isocyano-p-chlorphenylessigsaeureaethylester

Chemical Property of α-Isocyano-p-chlorphenylessigsaeureaethylester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of α-Isocyano-p-chlorphenylessigsaeureaethylester

There total 1 articles about α-Isocyano-p-chlorphenylessigsaeureaethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-chlorobenzylisocyanide (39546-47-9) + Diethyl carbonate (105-58-8,76619-83-5) → α-Isocyano-p-chlorphenylessigsaeureaethylester (39533-35-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00951a030

Reference yield: 50.0%

α-Isocyano-p-chlorphenylessigsaeureaethylester (39533-35-2) + 1,3-diphenyl-2-propynone (7338-94-5) → C26H20ClNO3

Guidance literature:

With (S)-(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(4-(pyrrolidin-1-yl)pyridin-3-yl)methanone; dibutylmagnesium; In n-heptane; toluene; at 40 ℃; for 12h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201900481

Reference yield:

α-Isocyano-p-chlorphenylessigsaeureaethylester (39533-35-2) → 2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8)

Guidance literature:

Multistep reaction; (i) aq. HCl, MeOH, (ii) NaOH;

DOI:10.1021/jo00951a030

upstream raw materials:

p-chlorobenzylisocyanide

Diethyl carbonate

Downstream raw materials:

2-(4-Chlorophenyl)glycine