CID 657296

Base Information

• Chemical Name: CID 657296
• CAS No.: 63659-19-8
• Molecular Formula: C18H29NO3^.HCl
• Molecular Weight: 343.894
• Hs Code.: 2922504500
• Mol file: 63659-19-8.mol

Synonyms:AKOS026749833

Chemical Property of CID 657296

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 8.26E-09mmHg at 25°C
• Melting Point: 116°
• Boiling Point: 448 °C at 760 mmHg
• Flash Point: 224.7 °C
• PSA: 50.72000
• LogP: 3.58630
• Storage Temp.: Store at RT
• Solubility.: H2O: 36 mg/mL, soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 11
• Exact Mass: 343.1914215
• Heavy Atom Count: 23
• Complexity: 286

Purity/Quality:

99% ^*data from raw suppliers

Betaxolol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.[Cl-]
• Description: Betaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid of intrinsic sympathomimetic and membrane stabilizing properties. Its long duration of action permits once-daily dosing in mild to moderate hypertension. It is also being evaluated in glaucoma. Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
• Uses: Betaxolol Hydrochloride, a cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma. antifungal

Technology Process of CID 657296

There total 2 articles about CID 657296 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

betaxolol (63659-18-7) → betaxolol Hydrochloride (63659-19-8)

Guidance literature:

With hydrogenchloride; In acetone; at 10 - 15 ℃; pH=2.0;

Reference yield:

→ betaxolol Hydrochloride (63659-19-8)

Guidance literature:

Reference yield:

betaxolol Hydrochloride (63659-19-8) → betaxolol (63659-18-7)

Guidance literature:

With Dowex Marathon 11 chloride form; In water;

DOI:10.1107/S2053229618017084

upstream raw materials:

betaxolol

Downstream raw materials:

1--N-isopropylamino>-3--2-propanol

1-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-3-isopropylamino-propan-2-one oxime

1-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-3-isopropylamino-propan-2-one oxime

3-[4-(2-Cyclopropylmethoxy-ethyl)-phenoxy]-2-[(Z)-hydroxyimino]-propionaldehyde oxime

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES". Page/Page column 9. . Retrieved 2010/04/06.