PYRAZOL-1-YL-METHANOL

Base Information

• Chemical Name: PYRAZOL-1-YL-METHANOL
• CAS No.: 1120-82-7
• Molecular Formula: C4H6 N2 O
• Molecular Weight: 98.1044
• Hs Code.: 2933199090
• Mol file: 1120-82-7.mol

Synonyms:Pyrazole-1-methanol(7CI,8CI); 1-(Hydroxymethyl)pyrazole; 1-Pyrazolylmethanol;N-(Hydroxymethyl)pyrazole; NSC 50562

Chemical Property of PYRAZOL-1-YL-METHANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 89-90℃ (ethanol water )
• Boiling Point: 214.0±23.0℃ (760 Torr)
• PKA: 13.14±0.10(Predicted)
• Flash Point: 83.2±22.6℃
• PSA: 38.05000
• Density: 1.21±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: -0.16710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1H-Pyrazol-1-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRAZOL-1-YL-METHANOL

There total 3 articles about PYRAZOL-1-YL-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

NH-pyrazole (288-13-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → pyrazole-1-methanol (1120-82-7)

Guidance literature:

In dichloromethane; for 120h; Reflux;

DOI:10.1016/j.poly.2012.05.014

Reference yield: 94.0%

→ pyrazole-1-methanol (1120-82-7)

Guidance literature:

Reference yield: 90.0%

NH-pyrazole (288-13-1) + methanol (67-56-1) → pyrazole-1-methanol (1120-82-7)

Guidance literature:

With formaldehyd; In water; at 25 ℃; for 4h;

upstream raw materials:

NH-pyrazole

formaldehyd

methanol

Downstream raw materials:

1-pyrazolylmethylchloride

Refernces

• 1、 Haldon, Estela,Delgado-Rebollo, Manuela,Prieto, Auxiliadora,Alvarez, Eleuterio,Maya, Celia,Nicasio, M. Carmen,Perez, Pedro J.. "Synthesis, structural characterization, reactivity, and catalytic properties of copper(I) complexes with a series of tetradentate tripodal tris(pyrazolylmethyl)amine ligands". . p. 4192 - 4201. Retrieved 2014.
• 2、 Ording-Wenker, Erica C. M.,Siegler, Maxime A.,Bouwman, Elisabeth. "Coordination of new disulfide ligands to CuIand CuII: Does a CuII μ-thiolate complex form?". . p. 193 - 202. Retrieved 2015.
• 3、 Lupsor, Simona,Aonofriesei, Florin,Iovu, Mircea. "Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole". . p. 3035 - 3042,8. Retrieved 2012.
• 4、 Pham, Pierce,Hilty, Christian. "Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates". supporting information. p. 15466 - 15469. Retrieved 2020/12/25.
• 5、 Tuskaev, Vladislav A.,Zubkevich, Sergei V.,Saracheno, Daniele,Gagieva, Svetlana Ch.,Dorovatovskii, Pavel V.,Kononova, Elena G.,Khrustalev, Victor N.,Zarubin, Dmitry N.,Bulychev, Boris M.,Kissin, Yury V.. "Nickel(II) complexes with tripodal NNN ligands as homogenous and supported catalysts for ethylene oligomerization". . p. 29 - 38. Retrieved 2019/01/04.