(3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

Base Information

• Chemical Name: (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester
• CAS No.: 1254361-97-1
• Molecular Formula: C₂₇H₃₂FNO₄
• Molecular Weight: 453.554
• Mol file: 1254361-97-1.mol

Synonyms:(3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

Chemical Property of (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

There total 2 articles about (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester (1254361-93-7) → (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester (1254361-97-1)

Guidance literature:

(S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester; With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 3h; Inert atmosphere;

With water; sodium hydrogencarbonate; In tetrahydrofuran; methanol; n-heptane; ethyl acetate; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo101542y

Reference yield: 46.0%

(S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester (1254361-93-7) → (3S,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester (1254362-01-0) + (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester (1254361-97-1)

Guidance literature:

With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; at -40 ℃; for 16h; optical yield given as %de;

DOI:10.1021/jo101542y

Reference yield: 78.0%

(3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester (1254361-97-1) → fluvastatin sodium (94061-80-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at -40 ℃; for 2h;

DOI:10.1021/jo101542y

upstream raw materials:

(S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

Downstream raw materials:

fluvastatin sodium

Refernces