Technology Process of [2R,4R,5R]-3,4-dimethoxy-benzoic acid 7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-hepthyl ester
There total 3 articles about [2R,4R,5R]-3,4-dimethoxy-benzoic acid 7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-hepthyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4-dimethoxybenzoic acid (2R)-2-methyl-3-oxopentyl ester;
With
dicyclohexylboron chloride; triethylamine;
In
diethyl ether;
at 0 ℃;
for 1h;
3-Benzyloxypropanal;
In
diethyl ether;
at -78 - -20 ℃;
for 13h;
DOI:10.1021/jo035668l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 88 percent / pyridine; DMAP / CH2Cl2 / 0.67 h / 0 - 20 °C
2.1: cHex2BCl; Et3N / diethyl ether / 1 h / 0 °C
2.2: 81 percent / diethyl ether / 13 h / -78 - -20 °C
With
pyridine; dmap; dicyclohexylboron chloride; triethylamine;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo035668l
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 70 percent / LiAlH4 / diethyl ether / 0.25 h / -78 °C
2.1: 88 percent / pyridine; DMAP / CH2Cl2 / 0.67 h / 0 - 20 °C
3.1: cHex2BCl; Et3N / diethyl ether / 1 h / 0 °C
3.2: 81 percent / diethyl ether / 13 h / -78 - -20 °C
With
pyridine; dmap; lithium aluminium tetrahydride; dicyclohexylboron chloride; triethylamine;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo035668l
