Rilmenidine

Base Information

• Chemical Name: Rilmenidine
• CAS No.: 54187-04-1
• Molecular Formula: C10H16N2O
• Molecular Weight: 180.25
• Hs Code.: 2934999090
• European Community (EC) Number: 259-021-0
• NSC Number: 664312
• UNII: P67IM25ID8
• DSSTox Substance ID: DTXSID3045194
• Nikkaji Number: J23.709D
• Wikipedia: Rilmenidine
• Wikidata: Q967973
• NCI Thesaurus Code: C75240
• Pharos Ligand ID: 81WDH495P2XG
• Metabolomics Workbench ID: 67840
• ChEMBL ID: CHEMBL289480
• Mol file: 54187-04-1.mol

Synonyms:2-(N-(dicyclopropylmethyl)amino)oxazoline;2-(N-(dicyclopropylmethyl)amino)oxazoline phosphate salt;Hyperium;oxaminozoline;rilmenidine;rilmenidine phosphate;S 3341;S 3341 3;S-3341;S-3341-3;S3341;S33413

Chemical Property of Rilmenidine

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 2.53E-27mmHg at 25°C
• Melting Point: 106 - 107oC
• Boiling Point: 355.469 °C at 760 mmHg
• PKA: 7.88±0.50(Predicted)
• Flash Point: 168.782 °C
• PSA: 33.62000
• Density: 1.455 g/cm³
• LogP: 0.97730
• Storage Temp.: Store at -20°C
• Solubility.: H2O: 7.3 mg/mL
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 180.126263138
• Heavy Atom Count: 13
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

RILMENIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(C2CC2)NC3=NCCO3
• Recent ClinicalTrials: Sympathetic Nerve Activity in Renal Failure
• Recent EU Clinical Trials: Huntington's Disease Rilmenidine Safety Trial
• Description: Rilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist profile, reportedly useful in the management of mild to moderate hypertension. Its fmt-line indication is possible because of the clear dissociation of its antihypertensive activity from other neurophannacological effects.
• Uses: I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine

Technology Process of Rilmenidine

There total 2 articles about Rilmenidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

S 11460 (54187-44-9) + 1-(2-chloroethyl)-3-(dicyclopropylmethyl)urea (54187-03-0) → rilmenidine (54187-04-1)

Guidance literature:

With thionyl chloride; ammonia; In chloroform; water;

Reference yield:

→ rilmenidine (54187-04-1)

Guidance literature:

d.N-β-Chlor-ethylharnstoff durch Cycl.;

upstream raw materials:

S 11460

1-(2-chloroethyl)-3-(dicyclopropylmethyl)urea

Refernces