(4-tert-butylphenyl)ethynyl bromide

Base Information

• Chemical Name: (4-tert-butylphenyl)ethynyl bromide
• CAS No.: 1085526-67-5
• Molecular Formula: C₁₂H₁₃Br
• Molecular Weight: 237.139
• Mol file: 1085526-67-5.mol

Synonyms:(4-tert-butylphenyl)ethynyl bromide

Chemical Property of (4-tert-butylphenyl)ethynyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-tert-butylphenyl)ethynyl bromide

There total 4 articles about (4-tert-butylphenyl)ethynyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-tert-Butylphenylacetylene (772-38-3) → (4-tert-butylphenyl)ethynyl bromide (1085526-67-5)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; Darkness;

DOI:10.1002/chem.201902213

Reference yield: 91.0%

3-(4-(tert-butyl)phenyl)propiolic acid (220006-53-1) → (4-tert-butylphenyl)ethynyl bromide (1085526-67-5)

Guidance literature:

With dibromamine-T; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2018.11.041

Reference yield: 91.0%

1-(tert-butyl)-4-(2,2-dibromovinyl)benzene → (4-tert-butylphenyl)ethynyl bromide (1085526-67-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201700217

upstream raw materials:

4-tert-Butylphenylacetylene

4-tert-Butylbenzaldehyde

3-(4-(tert-butyl)phenyl)propiolic acid

Downstream raw materials:

3-[(4-tert-butylphenyl)ethynyl]-1,3-oxazolidin-2-one

3,3'-(2-(4-tert-butylphenyl)ethene-1,1-diyl)dioxazolidin-2-one

1,4-bis(4-tert-butylphenyl)buta-1,3-diyne

1-(4-tert-butyl-phenylethynyl)-1H-imidazole

Refernces

• 1、 Han, Xiang-Lei,Zhou, Chu-Jun,Liu, Xu-Ge,Zhang, Shang-Shi,Wang, Honggen,Li, Qingjiang. "Regioselective Synthesis of 5-Aminooxazoles via Cp?Co(III)-Catalyzed Formal [3 + 2] Cycloaddition of N-(Pivaloyloxy)amides with Ynamides". . p. 6108 - 6111. Retrieved 2017.
• 2、 Xu, Hailong,Chen, Rui,Ruan, Hongjie,Ye, Ruyi,Meng, Ling-Guo. "Visible-Light-Promoted Formation of C—C and C—P Bonds Derived from Evolution of Bromoalkynes under Additive-Free Conditions: Synthesis of 1,1-Dibromo-1-en-3-ynes and Alkynylphosphine Oxides". supporting information. p. 873 - 878. Retrieved 2021/03/04.
• 3、 Yang, Yangyang,Schie?l, Jasmin,Zallouz, Sirine,G?ker, Verena,Gross, Jürgen,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.. "Gold-Catalyzed C(sp2)?C(sp) Coupling by Alkynylation through Oxidative Addition of Bromoalkynes". supporting information. p. 9624 - 9628. Retrieved 2019/07/05.