methyl 2-(2-pyridinyl)benzoate

Base Information

• Chemical Name: methyl 2-(2-pyridinyl)benzoate
• CAS No.: 98061-19-9
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.236
• Mol file: 98061-19-9.mol

Synonyms:methyl 2-(2-pyridinyl)benzoate

Chemical Property of methyl 2-(2-pyridinyl)benzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-(2-pyridinyl)benzoate

There total 23 articles about methyl 2-(2-pyridinyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-phenylpyridine (1008-89-5) + hydrazinecarboxylic acid methyl ester (6294-89-9) → methyl 2-(2-pyridinyl)benzoate (98061-19-9)

Guidance literature:

With oxone||potassium monopersulfate triple salt; palladium diacetate; silver nitrate; In acetonitrile; at 90 ℃; for 16h; Reagent/catalyst; Solvent; regioselective reaction; Catalytic behavior; Sealed tube; Green chemistry;

DOI:10.1002/ejoc.202000530

Reference yield: 80.0%

methanol (67-56-1) + 2-phenylpyridine (1008-89-5) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → methyl 2-(2-pyridinyl)benzoate (98061-19-9)

Guidance literature:

With sodium acetate; palladium diacetate; silver carbonate; p-benzoquinone; In 1,2-dichloro-ethane; at 80 ℃; for 18h; Solvent; Reagent/catalyst; Temperature; regioselective reaction; Sealed tube;

DOI:10.1002/adsc.201600395

Reference yield: 73.0%

2-phenylpyridine (1008-89-5) + carbon dioxide (124-38-9,18923-20-1) + methoxydimethylaluminium (6063-88-3) + diazomethyl-trimethyl-silane (18107-18-1) → 2-(2-methylphenyl)pyridine (10273-89-9) + methyl 2-(2-pyridinyl)benzoate (98061-19-9)

Guidance literature:

2-phenylpyridine; carbon dioxide; methoxydimethylaluminium; With chlorobis(cyclooctene)rhodium(I) dimer; tricyclohexylphosphine; In N,N-dimethyl acetamide; at 70 ℃; for 8h; under 760.051 Torr; Inert atmosphere;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; at 0 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja109097z

upstream raw materials:

diazomethane

2-(2-Pyridinyl)benzoic Acid

2-iodopyridine

benzoic acid methyl ester

Downstream raw materials:

Toluene-4-sulfonate1-amino-2-(2-methoxycarbonyl-phenyl)-pyridinium;

2-(2-methylphenyl)pyridine

1-(2-(pyridin-2-yl)phenyl)methanol

Refernces

• 1、 Zhang, Xitao,Feng, Xiujuan,Zhou, Chuancheng,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming. "Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions". supporting information. p. 7095 - 7099. Retrieved 2018/11/23.
• 2、 Zhou, Wei,Li, Pinhua,Zhang, Yicheng,Wang, Lei. "Palladium-catalyzed direct alkoxycarbonylation of aromatic C-H bonds via selective C-C cleavage of a-keto esters". . p. 2343 - 2352. Retrieved 2013/10/01.