3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester

Base Information

• Chemical Name: 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester
• CAS No.: 372523-01-8
• Molecular Formula: C₁₅H₁₄Cl₂O₅S
• Molecular Weight: 377.245
• Mol file: 372523-01-8.mol

Synonyms:3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester

Chemical Property of 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester

There total 2 articles about 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-ethylresorcinol (4299-72-3) + 3,5-dichloro-2-methoxybenzene-1-sulfonyl chloride (19116-94-0) → 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester (372523-01-8)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; at 20 ℃; for 48h;

DOI:10.1021/jm010833f

Reference yield:

3,5-dihydroxyacetophenone (51863-60-6) → 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester (372523-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / H₂; aq. HCl / Pd/C / 16 h / 20 °C

2: 22 percent / aq. NaHCO₃ / diethyl ether / 48 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In diethyl ether;

DOI:10.1021/jm010833f

Reference yield: 17.0%

2-allyloxy-4-(2-hydroxyethyl)benzonitrile (372522-92-4) + 3,5-dichloro-2-methoxybenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester (372523-01-8) → 3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]-5-ethylphenyl ester (372523-17-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm010833f

upstream raw materials:

5-ethylresorcinol

3,5-dichloro-2-methoxybenzene-1-sulfonyl chloride

3,5-dihydroxyacetophenone

Downstream raw materials:

3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]-5-ethylphenyl ester

3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

Refernces