dehydrocycloheximide

Base Information

• Chemical Name: dehydrocycloheximide
• CAS No.: 1154-58-1
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 1154-58-1.mol

Synonyms:dehydrocycloheximide

Chemical Property of dehydrocycloheximide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dehydrocycloheximide

There total 2 articles about dehydrocycloheximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(2-Chloro-3,5-dimethyl-6-oxo-cyclohex-1-enyl)-2-oxo-ethyl]-piperidine-2,6-dione (170807-02-0) → trans-2,4-dimethyl-6-(2,6-dioxopiperidin-4-yl-acetyl)cyclohexanone (1154-58-1,3005-28-5,3183-38-8,3246-93-3) + cis-2,4-dimethyl-6-(2,6-dioxopiperidin-4-yl-acetyl)cyclohexanone

Guidance literature:

With hydrogen; Pd-BaSO₄; In tetrahydrofuran;

DOI:10.1023/A:1012586621401

Reference yield:

3-[2-(2-hyroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide (526-02-3) → dehydrocycloheximide (1154-58-1)

Guidance literature:

With enoylreductase;

DOI:10.1021/ol501179w

Reference yield:

dehydrocycloheximide (1154-58-1) → Cycloheximide (66-81-9)

Guidance literature:

With ketoreductase; NADPH; In dimethyl sulfoxide; at 24 ℃; for 0.166667h; pH=5.8 - 8; Kinetics; Enzymatic reaction;

DOI:10.1021/ol501179w

upstream raw materials:

4-[2-(2-Chloro-3,5-dimethyl-6-oxo-cyclohex-1-enyl)-2-oxo-ethyl]-piperidine-2,6-dione

3-[2-(2-hyroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide

Downstream raw materials:

Cycloheximide

Refernces

• 1、 Buravskaya,Lakhvich. "Synthesis of dehydro derivatives of cycloheximide and inactone". . p. 724 - 728. Retrieved 2007/10/03.