thymidine diphosphate-6-deoxy-xylo-4-hexulose

Base Information

• Chemical Name: thymidine diphosphate-6-deoxy-xylo-4-hexulose
• CAS No.: 7132-58-3
• Molecular Formula: C₁₆H₂₄N₂O₁₅P₂
• Molecular Weight: 546.318
• Mol file: 7132-58-3.mol

Synonyms:

Chemical Property of thymidine diphosphate-6-deoxy-xylo-4-hexulose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thymidine diphosphate-6-deoxy-xylo-4-hexulose

There total 12 articles about thymidine diphosphate-6-deoxy-xylo-4-hexulose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

dTDP-glucose disodium salt → thymidine diphosphate 4-keto-6-deoxy-α-D-glucose (16752-71-9,7132-58-3)

Guidance literature:

With recombinant Salmonella enterica RfbB; NADP; at 30 ℃; for 2h; pH=8; aq. buffer; Enzymatic reaction;

DOI:10.1021/bi101336u

Reference yield: 71.0%

thymidine 5'-(α-D-glucopyranosyl diphosphate) (2196-62-5) → thymidine diphosphate 4-keto-6-deoxy-α-D-glucose (16752-71-9,7132-58-3)

Guidance literature:

With Streptococcus pneumonia serotype 23F dTDP-Glc-4,6-dehydratase Cps₂₃FN; nicotinamide adenine dinucleotide; In aq. buffer; at 37 ℃; for 0.5h; pH=7.5; Enzymatic reaction;

DOI:10.1039/c6cc08366h

Reference yield:

thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) + α-D-glucopyranosyl-1-phosphate (59-56-3,27251-84-9,63779-58-8,262856-84-8) → thymidine diphosphate 4-keto-6-deoxy-α-D-glucose (16752-71-9,7132-58-3)

Guidance literature:

With acetylphosphoric acid; recombinant N-terminally histidine-tagged acetate kinase; recombinant N-terminally histidine-tagged Escherichia coli RmlB TDP-D-glucose-4,6-dehydratase; recombinant N-terminally histidine-tagged Salmonella typhimurium RfbA TDP-D-glucose synthase; recombinant N-terminally histidine-tagged thymidine monophosphate kinase; ATP; magnesium chloride; In water; at 37 ℃; for 0.5h; pH=7.5; aq. phosphate buffer;

DOI:10.1039/c0ob00854k

upstream raw materials:

C₂₀H₁₉O₁₀P

thymidine 5'-(α-D-glucopyranosyl diphosphate)

thymidine 5'-phosphate

α-D-glucopyranosyl-1-phosphate

Refernces

• 1、 Ruszczycky, Mark W.,Choi, Sei-Hyun,Mansoorabadi, Steven O.,Liu, Hung-Wen. "Mechanistic studies of the radical S-adenosyl-l-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-d-quinovose". . p. 7292 - 7295. Retrieved 2011.
• 2、 Ruszczycky, Mark W.,Choi, Sei-Hyun,Liu, Hung-Wen. "Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme desll". . p. 2359 - 2369. Retrieved 2010.
• 3、 Li, Siqiang,Wang, Hong,Ma, Juncai,Gu, Guofeng,Chen, Zonggang,Guo, Zhongwu. "One-pot four-enzyme synthesis of thymidinediphosphate-l-rhamnose". supporting information. p. 13995 - 13998. Retrieved 2016/12/09.