1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate

Base Information

• Chemical Name: 1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate
• CAS No.: 457068-92-7
• Molecular Formula: C12H27NO3S
• Molecular Weight: 265.417
• Mol file: 457068-92-7.mol

Synonyms:Cyclohexanamine, 1,3,3,5,5-pentamethyl-, methanesulfonate;1,3,3,5,5-Pentamethylcyclohexanamine methanesulfonate;

Chemical Property of 1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate

Chemical Property:

• PSA: 88.77000
• LogP: 4.22520

Purity/Quality:

99%, ^*data from raw suppliers

Neramexane mesylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate

There total 5 articles about 1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + neramexane (219810-59-0) → Neramexane mesylate (457068-92-7)

Guidance literature:

In ethyl acetate; at 0 - 5 ℃; for 1h;

Reference yield:

3,5,5-Trimethylcyclohex-2-en-1-one (78-59-1) → Neramexane mesylate (457068-92-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C

2.1: tetrahydrofuran / 5 - 15 °C

3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C

4.1: hydrogenchloride; thiourea / water / 6 h / Reflux

4.2: pH 7

5.1: ethyl acetate / 1 h / 0 - 5 °C

With hydrogenchloride; copper(l) iodide; sulfuric acid; thiourea; lithium chloride; In tetrahydrofuran; water; acetic acid; ethyl acetate;

Reference yield:

3,3,5,5-tetramethylcyclohexanone (14376-79-5) → Neramexane mesylate (457068-92-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 5 - 15 °C

2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C

3.1: hydrogenchloride; thiourea / water / 6 h / Reflux

3.2: pH 7

4.1: ethyl acetate / 1 h / 0 - 5 °C

With hydrogenchloride; sulfuric acid; thiourea; In tetrahydrofuran; water; acetic acid; ethyl acetate;

upstream raw materials:

3,5,5-Trimethylcyclohex-2-en-1-one

methanesulfonic acid

neramexane

3,3,5,5-tetramethylcyclohexanone

Downstream raw materials:

neramexane

Refernces

• 1、 -. "METHOD OF PREPARING NERAMEXANE". . . Retrieved 2011/02/24.