Technology Process of 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-ol
There total 8 articles about 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.25h;
3,3-dimethylbutyrylaldehyde;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 3 h / 0 °C
3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C
6.1: copper(I) bromide; sodium / N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux
7.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C
7.2: 12.25 h / 0 - 25 °C
8.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
8.2: 1 h / -78 °C
With
pyridine; n-butyllithium; formic acid; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; bromine; sodium; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(I) bromide; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C
1.2: 12.25 h / 0 - 25 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C
2.2: 1 h / -78 °C
With
n-butyllithium; tetrabutylammomium bromide; sodium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane;