2-(4-fluorophenyl)-4-phenylthiophene

Base Information

• Chemical Name: 2-(4-fluorophenyl)-4-phenylthiophene
• CAS No.: 1415605-87-6
• Molecular Formula: C₁₆H₁₁FS
• Molecular Weight: 254.328
• Mol file: 1415605-87-6.mol

Synonyms:2-(4-fluorophenyl)-4-phenylthiophene

Chemical Property of 2-(4-fluorophenyl)-4-phenylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-4-phenylthiophene

There total 6 articles about 2-(4-fluorophenyl)-4-phenylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(4-fluorophenyl)thiophene (58861-48-6) + phenylboronic acid (98-80-6) → 2-(4-fluorophenyl)-4-phenylthiophene (1415605-87-6)

Guidance literature:

With palladium(II) trifluoroacetate; cesium trifluoroacetate; p-benzoquinone; silver(l) oxide; In acetic acid; trifluoroacetic acid; at 20 ℃; for 15h; regioselective reaction;

DOI:10.1002/chem.201503067

Reference yield: 67.0%

2-(4-fluorophenyl)thiophene (58861-48-6) + diphenyliodonium tetrafluoroborate → 2-(4-fluorophenyl)-4-phenylthiophene (1415605-87-6)

Guidance literature:

With 5%-palladium/activated carbon; In ethanol; at 60 ℃; for 22h; regioselective reaction;

DOI:10.1002/anie.201309305

Reference yield: 43.0%

C16H15F → 2-(4-fluorophenyl)-4-phenylthiophene (1415605-87-6)

Guidance literature:

With potassium disulfide; dimethyl sulfoxide; at 140 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.orglett.8b03078

upstream raw materials:

2-(4-fluorophenyl)thiophene

trimethylphenylsilane

4-fluoro-1-iodobenzene

phenylboronic acid

Refernces

• 1、 Schnapperelle, Ingo,Breitenlechner, Stefan,Bach, Thorsten. "Kinetic Studies on the Palladium(II)-Catalyzed Oxidative Cross-Coupling of Thiophenes with Arylboron Compounds and Their Mechanistic Implications". supporting information. p. 18407 - 18416. Retrieved 2015/12/24.
• 2、 Funaki, Kenji,Sato, Tetsuo,Oi, Shuichi. "Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes". supporting information. p. 6186 - 6189. Retrieved 2013/02/23.