Mazindol

Base Information

• Chemical Name: Mazindol
• CAS No.: 22232-71-9
• Molecular Formula: C16H13ClN2O
• Molecular Weight: 284.745
• Hs Code.: 2933910016
• European Community (EC) Number: 244-857-0
• UNII: C56709M5NH
• DSSTox Substance ID: DTXSID1023237
• Nikkaji Number: J11.418I
• Wikipedia: Mazindol
• Wikidata: Q255680
• NCI Thesaurus Code: C66057
• Pharos Ligand ID: AB8P8HM2N8RA
• Metabolomics Workbench ID: 42911
• ChEMBL ID: CHEMBL781
• Mol file: 22232-71-9.mol

Synonyms:AN-448;AN448;Diestet;Mazanor;Mazindol;Mazindole;Sanjorex;Sanorex;Solucaps;Teronac;Teronak

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Mazindol

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 4.57E-09mmHg at 25°C
• Melting Point: 215-217°C
• Refractive Index: 1.704
• Boiling Point: 454.908 °C at 760 mmHg
• PKA: pKa 8.6 (Uncertain)
• Flash Point: 228.921 °C
• PSA: 35.83000
• Density: 1.399 g/cm³
• LogP: 1.98270
• Storage Temp.: Controlled Substance, -20?C Freezer
• Solubility.: DMSO: 10 mg/mL
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 284.0716407
• Heavy Atom Count: 20
• Complexity: 419

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45

MSDS Files:

Useful:

• Canonical SMILES: C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O
• Recent ClinicalTrials: An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With Narcolepsy
• Recent EU Clinical Trials: Effet du mazindol sur le Trouble Déficit de l'Attention/Hyperactivité chez l'enfant : étude prospective pilote (phase II) d'efficacité, de tolérance et de pharmacocinétique
• Recent NIPH Clinical Trials: Pleiotropic effects of mazindol against gastrointestinal and appetite control peptides
• Uses: Clinical trials as appetite depressant. Anorexic; CNS stimulant. Controlled substance (stimulant).
• Therapeutic Function: Antiobesity

Technology Process of Mazindol

There total 5 articles about Mazindol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sulfate salt of 4'-chloro-2-(2-imidazolin-2-yl)benzophenone + 9b-(4-chloro-phenyl)-1-(toluene-4-sulfonyl)-1,2,3,9b-tetrahydro-imidazo[2,1-a]isoindol-5-one (22590-16-5) → Mazindol (22232-71-9)

Guidance literature:

In sulfuric acid;

Reference yield:

2-phenyl-2-imidazoline (936-49-2) + Methyl 4-chlorobenzoate (1126-46-1) → Mazindol (22232-71-9)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 50 deg C, 3 h, 2.) 50 deg C, 6 h;

DOI:10.1021/jo00147a027

Reference yield:

9b-(p-chlorophenyl)-1,2,3,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one (6038-49-9) → Mazindol (22232-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: sulfuric acid

With pyridine; In sulfuric acid;

upstream raw materials:

2-phenyl-2-imidazoline

Methyl 4-chlorobenzoate

ethylenediamine

2-(4-chlorobenzoyl)-benzaldehyde

Downstream raw materials:

4'-chloro-2-(imidazolin-2-yl)benzophenone hydrochloride

Refernces

• 1、 -. "USE OF ISOINDOLES FOR THE TREATMENT OF NEUROBEHAVIORAL DISORDERS". . . Retrieved 2009/12/28.
• 2、 Houlihan, William J.,Parrino, Vincent A.. "Directed Lithiation of 2-Phenyl- and 2-(o-Methylphenyl)imidazoline". . p. 5177 - 5180. Retrieved 2007/10/02.