(2-BROMOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE

Base Information

• Chemical Name: (2-BROMOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE
• CAS No.: 7301-93-1
• Molecular Formula: C20H19BrP+
• Molecular Weight: 450.153
• Mol file: 7301-93-1.mol

Synonyms:

Chemical Property of (2-BROMOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE

Chemical Property:

• Melting Point: 186-189℃
• PSA: 13.59000
• LogP: 1.37940
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

98%min ^*data from raw suppliers

(2-Bromoethyl)triphenylphosphoniumbromide 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Bromoethyl)triphenylphosphonium bromide is used as pharmaceutical intermediates.

Technology Process of (2-BROMOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE

There total 4 articles about (2-BROMOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethylene dibromide (106-93-4) + triphenylphosphine (603-35-0) → (2-bromoethyl)triphenylphosphonium bromide (7301-93-1)

Guidance literature:

at 90 ℃; for 8h;

Reference yield:

triphenylphosphine (603-35-0) → (2-bromoethyl)triphenylphosphonium bromide (7301-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: aq. HBr / Heating

With hydrogen bromide; In benzene;

DOI:10.1016/S0022-328X(00)88730-6

Reference yield:

2-(hydroxyethyl)triphenylphosphonium bromide (7237-34-5) → (2-bromoethyl)triphenylphosphonium bromide (7301-93-1)

Guidance literature:

With water; hydrogen bromide;

DOI:10.1016/S0022-328X(00)88730-6

upstream raw materials:

2-(hydroxyethyl)triphenylphosphonium bromide

ethylene dibromide

triphenylphosphine

Downstream raw materials:

vinyltriphenylphosphonium bromide

Refernces

• 1、 Dubois,Lin,Beisler. "Synthesis and antitumor properties of some isoindolylalkylphosphonium salts". . p. 303 - 306. Retrieved 2007/10/04.