Technology Process of (2S)-2-methyl-6-phenyl-2,3,4,5-tetrahydropyridine
There total 3 articles about (2S)-2-methyl-6-phenyl-2,3,4,5-tetrahydropyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-alanin; formate dehydrogenase from Candida boidinii; ω-transaminase from Chromobacterium violaceum; recombinant alanine dehydrogenase; pyridoxal 5'-phosphate; NAD; ammonium formate;
at 30 ℃;
for 26h;
pH=7;
optical yield given as %ee;
stereoselective reaction;
aq. phosphate buffer;
DOI:10.1002/anie.201202375
- Guidance literature:
-
With
Escherichia coli overexpressed (R)-Arthrobacter (ArRmut11);
In
aq. phosphate buffer; dimethyl sulfoxide;
at 30 ℃;
pH=7.5;
Overall yield = 61 %; regioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/chem.201202793
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran; diethyl ether / 12 h / -78 °C / Inert atmosphere
2: formate dehydrogenase from Candida boidinii; ω-transaminase from Chromobacterium violaceum; recombinant alanine dehydrogenase; L-alanin; pyridoxal 5'-phosphate; NAD; ammonium formate / 26 h / 30 °C / pH 7 / aq. phosphate buffer
With
L-alanin; formate dehydrogenase from Candida boidinii; ω-transaminase from Chromobacterium violaceum; recombinant alanine dehydrogenase; pyridoxal 5'-phosphate; NAD; ammonium formate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1002/anie.201202375