Technology Process of 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine
There total 3 articles about 4-[6-(3,4-difluorophenyl)-2-methylpyrrolo[2,3-e]pyrimidin-4-yl]morpholine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
TiCl4;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: nitric acid; trifluoroacetic acid / water
2: trichlorophosphate / n-heptane; toluene
3: stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine / TiCl4 / N,N-dimethyl-formamide
With
nitric acid; stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;
TiCl4;
In
n-heptane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trichlorophosphate / n-heptane; toluene
2: stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine / TiCl4 / N,N-dimethyl-formamide
With
stannous chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
TiCl4;
In
n-heptane; N,N-dimethyl-formamide; toluene;