benzyl(diethyl)phosphine oxide

Base Information

• Chemical Name: benzyl(diethyl)phosphine oxide
• CAS No.: 4519-78-2
• Molecular Formula: C₁₁H₁₇OP
• Molecular Weight: 196.229
• Mol file: 4519-78-2.mol

Synonyms:benzyl(diethyl)phosphine oxide

Chemical Property of benzyl(diethyl)phosphine oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl(diethyl)phosphine oxide

There total 11 articles about benzyl(diethyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C11H17OP → benzyl(diethyl)phosphine oxide (4519-78-2)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In chloroform; at 25 ℃; for 72h;

DOI:10.1002/anie.200250270

Reference yield: 85.0%

C11H17OP → diethylphosphine oxide (7215-33-0) + benzyl(diethyl)phosphine oxide (4519-78-2)

Guidance literature:

With trimethylsilyl bromide; at 80 ℃; for 18h;

DOI:10.1021/ol0342913

Reference yield: 17.0%

ethyl bromide (74-96-4) + benzyl chloride (100-44-7) → triethylphosphine oxide (597-50-2) + tribenzylphosphine oxide (4538-55-0) + benzyl(diethyl)phosphine oxide (4519-78-2) + dibenzyl(ethyl)phosphine oxide

Guidance literature:

With phosphorus; N-benzyl-N,N,N-triethylammonium chloride; In 1,4-dioxane; potassium hydroxide; at 65 - 75 ℃; for 4h;

DOI:10.1007/BF02495786

upstream raw materials:

diethyl-benzyl-phosphine

nitric acid

ethyl bromide

benzyl chloride

Downstream raw materials:

diethyl-benzyl-phosphine

(E)-1,2-diphenyl-ethene

diethylphosphinic acid

Refernces

• 1、 Renard, Pierre-Yves,Vayron, Philippe,Mioskowski, Charles. "Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement". . p. 1661 - 1664. Retrieved 2007/10/03.
• 2、 Gusarova,Shaikhudinova,Ivanova,Reutskaya,Albanov,Trofimov. "Reactions of elemental phosphorus and phosphines with electrophiles in superbasic systems: XII. Synthesis of unsymmetrical tertiary phosphine oxides from red phosphorus and organyl halides". . p. 718 - 720. Retrieved 2007/10/03.