2-(2,4-Dichlorophenoxy)acetamide

Base Information

• Chemical Name: 2-(2,4-Dichlorophenoxy)acetamide
• CAS No.: 1982-42-9
• Molecular Formula: C8H7 Cl2 N O2
• Molecular Weight: 220.055
• Hs Code.: 2924299090
• European Community (EC) Number: 217-842-1
• NSC Number: 3533
• UNII: QV37THH6SK
• DSSTox Substance ID: DTXSID00173541
• Nikkaji Number: J7.839E
• Wikidata: Q83043599
• Mol file: 1982-42-9.mol

Synonyms:2-(2,4-Dichlorophenoxy)acetamide;Emid;1982-42-9;2,4-Dichlorophenoxyacetamide;2,4-D amide;Acetamide, 2-(2,4-dichlorophenoxy)-;2,4-DA;2,4-Dichlorophenoxyamide;AI3-18385;NSC 3533;EINECS 217-842-1;BRN 2052836;2,4-Dichlorophenoxyacetic acid amine salt;NSC-3533;4-06-00-00915 (Beilstein Handbook Reference);(2,4-Dichlorophenoxy)acetamide;QV37THH6SK;Oprea1_231652;2,4-dichloro-phenoxyacetamide;Acetamide,4-dichlorophenoxy)-;SCHEMBL277495;IFLab1_004124;DTXSID00173541;NSC3533;HMS1423L10;BAA98242;MFCD00464306;STK726490;AKOS001581095;LS-8898;SR-01000395608;SR-01000395608-1;Z19743974

Chemical Property of 2-(2,4-Dichlorophenoxy)acetamide

Chemical Property:

• Vapor Pressure: 1.13E-06mmHg at 25°C
• Boiling Point: 402°Cat760mmHg
• Flash Point: 196.9°C
• PSA: 52.32000
• Density: 1.422g/cm³
• LogP: 2.55780
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 218.9853839
• Heavy Atom Count: 13
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

2-(2,4-Dichlorophenoxy)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)OCC(=O)N
• Uses: 2-(2,4-Dichlorophenoxy)acetamide is used in the investigation of the male rats reproductive function after herbicides 2,4-DA poisoning, hormonal changes in rats poisoned by herbicide 2,4-DA.

Technology Process of 2-(2,4-Dichlorophenoxy)acetamide

There total 9 articles about 2-(2,4-Dichlorophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenoxyacetamide (621-88-5) → 2,4-dichlorophenoxyacetic acid amine (1982-42-9)

Guidance literature:

With chlorine; iron; acetic acid; at 40 ℃;

Reference yield:

syn-Benzaldehyd-O-(N-(o,p-dichlor-phenoxyacetyl)-carbamoyl)-oxim (23124-47-2) → 2,4-dichlorophenoxyacetic acid amine (1982-42-9)

Guidance literature:

With sodium ethanolate; In ethanol;

Reference yield:

2-(2,4-dichlorophenoxy)acetyl isocyanate (5843-44-7) → 2,4-dichlorophenoxyacetic acid amine (1982-42-9)

Guidance literature:

Multi-step reaction with 2 steps

2: NaOEt / ethanol

With sodium ethanolate; In ethanol;

upstream raw materials:

2,4-Dichlorophenoxyacetic acid

phenoxyacetamide

ethyl 2,4-dichlorophenoxyacetate

2,4-dichlorophenol

Downstream raw materials:

N-benzyl-2-(2,4-dichlorophenoxy)acetamide

N-((3-cyano-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazol-5-yl)carbamoyl)-2-(2,4-dichlorophenoxy) acetamide

butyl 3-(2-(2,4-dichlorophenoxy)acetamido)propanoate

[2-(2,4-Dichloro-phenoxy)-acetyl]-carbamic acid 2-chloro-allyl ester

Refernces

• 1、 Jiang, Dingxin,Zheng, Xiaohua,Shao, Guang,Ling, Zhang,Xu, Hanhong. "Discovery of a novel series of phenyl pyrazole inner salts based on fipronil as potential dual-target insecticides". . p. 3577 - 3583. Retrieved 2014/05/20.