Tetrahydro-5-oxo-2- furancarboxyli

Base Information

• Chemical Name: Tetrahydro-5-oxo-2- furancarboxyli
• CAS No.: 4344-84-7
• Molecular Formula: C₅H₆O₄
• Molecular Weight: 130.1
• Hs Code.: 2932190090
• Mol file: 4344-84-7.mol

Synonyms:2-Furoicacid, tetrahydro-5-oxo- (8CI);Glutaric acid, 2-hydroxy-, g-lactone (6CI,7CI);5-Oxo-2-tetrahydrofurancarboxylic acid;Butyrolactone-5-carboxylic acid;Butyrolactonecarboxylic acid;Carboxybutyrolactone;NSC 72000;Pentanedioicacid, 2-hydroxy-, g-lactone;Tetrahydro-5-oxo-2-furoic acid;a-Hydroxyglutaryl lactone;g-Butyrolactone-g-carboxylic acid;

Chemical Property of Tetrahydro-5-oxo-2- furancarboxyli

Chemical Property:

• Vapor Pressure: 5.71E-07mmHg at 25°C
• Melting Point: 48-50 °C
• Refractive Index: 1.505
• Boiling Point: 384.2 °C at 760 mmHg
• PKA: 3.11±0.20(Predicted)
• Flash Point: 184.6 °C
• PSA: 63.60000
• Density: 1.469 g/cm³
• LogP: -0.22340
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Water (Sparingly)

Purity/Quality:

97% ^*data from raw suppliers

Carboxybutyrolactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Carboxybutyrolactone is a structural analog of (±)-Paraconic Acid (P191200) and is used as a reagent in the synthesis of methylenecarboxybutyrolactones which have antibacterial activity.

Technology Process of Tetrahydro-5-oxo-2- furancarboxyli

There total 5 articles about Tetrahydro-5-oxo-2- furancarboxyli which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-oxo-tetrahydro-furan-2-carboxylic acid (4344-84-7,21461-84-7,53558-93-3,83829-70-3) + Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6)

Guidance literature:

With ammonia; Erhitzen des Reaktionsprodukts mit wss. Salzsaeure;

Reference yield:

Diethyl α-chloroglutarate (7209-05-4) + ammonia (7664-41-7) → 5-oxo-tetrahydro-furan-2-carboxylic acid (4344-84-7,21461-84-7,53558-93-3,83829-70-3) + Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6)

Guidance literature:

beim Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;

Reference yield:

α-ketoglutaric acid (328-50-7) → 1,5-pentanedioic acid (110-94-1) + 5-oxo-tetrahydro-furan-2-carboxylic acid (4344-84-7,21461-84-7,53558-93-3,83829-70-3) + 2-hydroxyglutaric acid (2889-31-8,636-67-9)

Guidance literature:

With platinum on carbon; hydrogen; In water; at 200 ℃; for 24h; under 22502.3 Torr;

DOI:10.1039/c6gc03222b

upstream raw materials:

Oxidized glutathione

Diethyl α-chloroglutarate

ammonia

L-glutamic acid

Downstream raw materials:

(R,S)-4-bromophenyl 5-oxotetrahydrofuran-2-carboxylate

1-Acetyl-1,5-dihydro-2H-pyrrolinon

2-buten-4-olide

(R,S)-N-(4-bromophenyl) 5-oxotetrahydrofuran-2-carboxamide

Refernces

• 1、 Lorenz, Peter,Conrad, Juergen,Bertrams, Julia,Berger, Melanie,Duckstein, Sarina,Meyer, Ulrich,Stintzing, Florian C.. "Investigations into the phenolic constituents of Dog's mercury (Mercurialis perennis L.) by LC-MS/MS and GC-MS analyses". experimental part. p. 60 - 71. Retrieved 2012/05/19.