(R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate

Base Information

• Chemical Name: (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate
• CAS No.: 38574-55-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 38574-55-9.mol

Synonyms:(R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate

Chemical Property of (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate

There total 41 articles about (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 2-(phenylmethyl)-2-aminopropionate (64282-11-7) → (S)-2-amino-2-methyl-3-phenylpropanoic acid (23239-35-2) + (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate (38574-55-9)

Guidance literature:

With α-chymotrypsin; In water; at 37 ℃; for 35h; pH=5.0;

DOI:10.1016/S0040-4039(00)87608-X

Reference yield: 79.0%

(2S,5R)-2,5-dihydro-2-isopropyl-3,6-dimethoxy-5-benzyl-5-methylpyrazine (81136-87-0) → L-Valine methyl ester (4070-48-8) + (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate (38574-55-9)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; In diethyl ether; for 72h; Ambient temperature;

Reference yield:

(3R,6S)-3-Benzyl-2,5-dimethoxy-3,6-dimethyl-3,6-dihydro-1,4-pyrazin (71785-56-3) → L-Alanine methyl ester (10065-72-2) + (R)-(-)-methyl 2-amino-2-methyl-3-phenylpropionate (38574-55-9)

Guidance literature:

With hydrogenchloride; Ambient temperature;

DOI:10.1016/S0040-4020(01)91926-X

upstream raw materials:

methanol

(R)-(+)-N-Acetyl-α-methyl-phenylalanin

(3R,6S)-3-Benzyl-2,5-dimethoxy-3,6-dimethyl-3,6-dihydro-1,4-pyrazin

(R)-2-amino-2-methyl-3-phenylpropanoic acid

Downstream raw materials:

C₁₆H₁₉⁽²⁾H₂BrN₂O₂

C₁₆H₁₉⁽²⁾H₂BrN₂O₂

C₁₆H₁₉⁽²⁾H₂BrN₂O₂

C₁₆H₁₉⁽²⁾H₂BrN₂O₂

Refernces

• 1、 Achard, Thierry R.J.,Clegg, William,Harrington, Ross W.,North, Michael. "Chiral salen ligands designed to form polymetallic complexes". experimental part. p. 133 - 144. Retrieved 2012/01/06.
• 2、 Davies, Stephen G.,Christopher Garner,Ouzman, Jaqueline V. A.,Roberts, Paul M.,Smith, Andrew D.,Snow, Emma J.,Thomson, James E.,Tamayo, Juan A.,Vickers, Richard J.. "Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates". . p. 2138 - 2147. Retrieved 2008/03/14.