ADIPIC ANHYDRIDE

Base Information

• Chemical Name: ADIPIC ANHYDRIDE
• CAS No.: 2035-75-8
• Molecular Formula: C6H8O3
• Molecular Weight: 128.128
• Hs Code.: 2917190090
• Mol file: 2035-75-8.mol

Synonyms:Adipicanhydride (6CI,7CI,8CI);Butanedicarboxylic anhydride;Cyclic adipic anhydride;Hexanedioic acid, anhydride;Hexanedioic anhydride;

Chemical Property of ADIPIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 2.44mmHg at 25°C
• Melting Point: 60-64 °C
• Refractive Index: 1.456
• Boiling Point: 262.1 °C at 760 mmHg
• Flash Point: 123.9 °C
• PSA: 43.37000
• Density: 1.183 g/cm³
• LogP: 0.63020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

Oxepane-2,7-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Adipic Anhydride is an esterifier for food starch in combination with acetic anhydride.

Technology Process of ADIPIC ANHYDRIDE

There total 17 articles about ADIPIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

hexanedioic acid dimethyl ester (627-93-0) → 1,6-hexanediol (629-11-8) + adipic anhydride (2035-75-8)

Guidance literature:

With water; hydrogen; In methanol; under 37503.8 Torr;

DOI:10.1016/j.apcata.2012.09.041

Reference yield: 84.0%

Adipic acid (124-04-9) → adipic anhydride (2035-75-8)

Guidance literature:

With thionyl chloride; sodium carbonate; In 1,4-dioxane; dichloromethane; for 3h; Heating;

DOI:10.1080/00397910701547904

Reference yield: 56.0%

Adipic acid (124-04-9) + acetic anhydride (108-24-7) → adipic anhydride (2035-75-8)

Guidance literature:

In acetic anhydride; for 14h; Heating / reflux;

upstream raw materials:

Adipic acid

acetic anhydride

cyclohexane

cyclohexanone

Downstream raw materials:

bis(4-nitrophenyl)adipate

mono-p-nitrophenyl adipate

adipic acid di-p-tolyl ester

adipic acid mono-p-tolyl ester

Refernces

• 1、 Ayral-Kaloustian, Semiramis,Gu, Jianxin,Lucas, Judy,Cinque, Michael,Gaydos, Christine,Zask, Arie,Chaudhary, Inder,Wang, Jianyao,Di, Li,Young, Mairead,Ruppen, Mark,Mansour, Tarek S.,Gibbons, James J.,Yu, Ker. "Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): Design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates". . p. 452 - 459. Retrieved 2010.
• 2、 Christmann, Mathias,He, Guoli,List, Benjamin. "Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**". supporting information. p. 13591 - 13596. Retrieved 2021/05/07.
• 3、 Zefirov,Evteeva, Yu. A.,Fatkulin,Schulz,Kuznetsov,Zefirova. "Synthesis, Antiproliferative Activity, and Effect on Carcinoma A549 Cell Microtubules of New Tubuloclustin Analogs". . p. 423 - 428. Retrieved 2019/09/16.