Chloramphenicol sodium succinate

Base Information

• Chemical Name: Chloramphenicol sodium succinate
• CAS No.: 982-57-0
• Deprecated CAS: 39095-30-2
• Molecular Formula: C15H16Cl2N2O8.Na
• Molecular Weight: 445.18
• European Community (EC) Number: 213-568-1
• UNII: 872109HX6B
• DSSTox Substance ID: DTXSID2024747
• Wikidata: Q27269783
• NCI Thesaurus Code: C47972
• RXCUI: 47998
• ChEMBL ID: CHEMBL1200729
• Mol file: 982-57-0.mol

Synonyms:chloramphenicol hemisuccinate;chloramphenicol monosuccinate;chloramphenicol sodium succinate;chloramphenicol succinate;chloramphenicol succinate sodium;levomycetin succinate

Chemical Property of Chloramphenicol sodium succinate

Chemical Property:

• Appearance/Colour: White powder
• Boiling Point: 716.3oC at 760mmHg
• Flash Point: 387oC
• PSA: 161.58000
• LogP: 0.90410
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: H2O: soluble50mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 444.0103151
• Heavy Atom Count: 28
• Complexity: 541

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chloramphenicol succinate sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
• Isomeric SMILES: C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
• Uses: Chloramphenicol Succinate Sodium is a derivative of Chloramphenicol (C325030) which are broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial. Chloramphenicol succinate sodium is the salt prepared from chloramphenicol succinate using the free carboxylic acid of the succinate which ionises and readily forms in weakly sodium hydroxide solutions. The sodium salt is the preferred formulation for pharmaceutical applications, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.