2'-(2,3-Dihydroxypropyloxy)acetanilide

Base Information

• Chemical Name: 2'-(2,3-Dihydroxypropyloxy)acetanilide
• CAS No.: 63905-15-7
• Molecular Formula: C11H15 N O4
• Molecular Weight: 225.24
• Hs Code.: 2924299090
• Mol file: 63905-15-7.mol

Synonyms:Acetanilide,2'-(2,3-dihydroxypropoxy)- (6CI)

Chemical Property of 2'-(2,3-Dihydroxypropyloxy)acetanilide

Chemical Property:

• Vapor Pressure: 9.1E-10mmHg at 25°C
• Boiling Point: 473.4°C at 760 mmHg
• Flash Point: 240.1°C
• PSA: 82.28000
• Density: 1.287g/cm³
• LogP: 1.02650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-(2,3-Dihydroxypropyloxy)acetanilide

There total 2 articles about 2'-(2,3-Dihydroxypropyloxy)acetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-acetyl-2-(2,3-epoxypropoxy)aniline (57682-11-8) → N-(2-(2,3-dihydroxypropoxy)phenyl)acetamide (63905-15-7)

Guidance literature:

With formic acid; at 80 ℃; for 2h;

DOI:10.1002/pola.27648

Reference yield: 70.0%

2-(acetylamino)phenol (614-80-2) + 3-monochloro-1,2-propanediol (96-24-2) → N-(2-(2,3-dihydroxypropoxy)phenyl)acetamide (63905-15-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 8h; Heating;

Reference yield: 83.0%

N-(2-(2,3-dihydroxypropoxy)phenyl)acetamide (63905-15-7) → 2-(2,3-dihydroxypropoxy)benzene aminium chloride (80491-49-2)

Guidance literature:

With hydrogenchloride; In water; at 70 ℃; for 24h;

DOI:10.1002/pola.27648

upstream raw materials:

2-(acetylamino)phenol

3-monochloro-1,2-propanediol

N-acetyl-2-(2,3-epoxypropoxy)aniline

Downstream raw materials:

2-hydroxy-3-(2-aminophenoxy)propanol

2-(2,3-dihydroxypropoxy)benzene aminium chloride

N-(i-Propylaminoacetyl)-o-aminophenylglycerylether

N-(t-Butylaminoacetyl)-o-aminophenylglycerylether

Refernces

• 1、 El-Said. "Synthesis of certain new propanediols and phenothiazines as potential tranquilizers". . p. 604 - 606. Retrieved 2007/10/02.