3-(o-tolyl)butanal

Base Information

• Chemical Name: 3-(o-tolyl)butanal
• CAS No.: 1174270-31-5
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 1174270-31-5.mol

Synonyms:3-(o-tolyl)butanal

Chemical Property of 3-(o-tolyl)butanal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(o-tolyl)butanal

There total 3 articles about 3-(o-tolyl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-(o-tolyl)but-2-en-1-ol (1174270-30-4) → 3-(o-tolyl)butanal (1174270-31-5)

Guidance literature:

With (1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; In tetrahydrofuran; at 23 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.04.130

Reference yield: 68.0%

2-methylphenyl bromide (95-46-5) + (Z)-1,1-diphenyl-2-(piperidin-1-yl)pent-3-en-1-ol → 3-(o-tolyl)butanal (1174270-31-5)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; at 90 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1055/a-1699-4766

Reference yield:

methyl 3-(o-tolyl)butanoate → 3-(o-tolyl)butanal (1174270-31-5)

Guidance literature:

methyl 3-(o-tolyl)butanoate; With diisobutylaluminium hydride; In hexanes; dichloromethane; at -78 ℃; for 1h;

With water; Rochelle's salt; In hexanes; dichloromethane; ethyl acetate; for 1h;

upstream raw materials:

(E)-3-(o-tolyl)but-2-en-1-ol

2-methylphenyl bromide

Downstream raw materials:

C₁₅H₂₀O₃

Refernces

• 1、 Martin, Ruben,Pericàs, Miquel A.,Sau, Miriam. "Pd-Catalyzed Arylation of 1,2-Amino Alcohol Derivatives via β-Carbon Elimination". supporting information. p. 52 - 56. Retrieved 2021/12/29.