(E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate

Base Information

• Chemical Name: (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate
• CAS No.: 94301-04-9
• Molecular Formula: C₁₉H₁₅NO₂
• Molecular Weight: 289.334
• Mol file: 94301-04-9.mol

Synonyms:(E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate

Chemical Property of (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate

There total 4 articles about (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-formylphenyl acetate (878-00-2) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4) → (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate (94301-04-9)

Guidance literature:

With oxygen; 4-nitro-benzoic acid; In para-xylene; at 120 ℃; for 16h; chemoselective reaction;

DOI:10.1002/cctc.201800202

Reference yield: 77.0%

Quinoline N-oxide (1613-37-2) + p-acetoxystyrene (2628-16-2) → (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate (94301-04-9)

Guidance literature:

With iron(II) sulfate; In toluene; at 100 ℃; for 16h; regioselective reaction; Sealed tube;

DOI:10.1039/d0gc03351k

Reference yield:

2-methylquinoline (91-63-4) + acetic anhydride (108-24-7) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (E)-4-(2-(quinolin-2-yl)vinyl)phenyl acetate (94301-04-9)

Guidance literature:

at 120 ℃; for 18h;

DOI:10.1021/jm00099a011

upstream raw materials:

2-methylquinoline

acetic anhydride

4-hydroxy-benzaldehyde

4-formylphenyl acetate

Downstream raw materials:

(E)-2-(2-(4-hydroxyphenyl)vinyl)quinoline

Refernces

• 1、 Fu, Dingqiang. "A novel quinoline-based colorimetric fluorescent probe for hydrogen sulfide". . p. 76 - 79. Retrieved 2021.
• 2、 Zamboni,Belley,Champion,Charette,DeHaven,Frenette,Gauthier,Jones,Leger,Masson,McFarlane,Metters,Pong,Piechuta,Rokach,Therien,Williams,Young. "Development of a novel series of styrylquinoline compounds as high- affinity leukotriene D4 receptor antagonists: Synthetic and structure- activity studies leading to the discovery of (±)-3-[[[3-[2-(7-chloro-2- quinolinyl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3- oxopropyl]thio]methyl]thio]propionic acid". . p. 3832 - 3844. Retrieved 2007/10/02.