3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether

Base Information

• Chemical Name: 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether
• CAS No.: 111264-15-4
• Molecular Formula: C₂₄H₃₈O₃
• Molecular Weight: 374.564
• Mol file: 111264-15-4.mol

Synonyms:3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether

Chemical Property of 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether

There total 1 articles about 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + Epietiocholanolone (571-31-3) → 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether (111264-15-4)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane;

Reference yield: 89.0%

methyl benzenesulfinate (670-98-4) + 3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether (111264-15-4) → (3S,5R,8R,9S,10S,13S,14S)-16-Benzenesulfinyl-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-one (111263-94-6)

Guidance literature:

With sodium hydride; In diethyl ether; for 4h; Ambient temperature;

Reference yield:

3β-hydroxy-5β-androstan-17-one 3-tetrahydropyranyl ether (111264-15-4) → 3β-hydroxy-16ξ-phenylsulfinyl-5β-androstan-17-one (111119-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NaH / diethyl ether / 4 h / Ambient temperature

2: 82 percent / aq. p-tolenesulfonic acid / methanol / 16 h

With sodium hydride; toluene-4-sulfonic acid; In methanol; diethyl ether;

upstream raw materials:

3,4-dihydro-2H-pyran

Epietiocholanolone

Downstream raw materials:

(3S,5R,8R,9S,10S,13S,14S)-16-Benzenesulfinyl-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-one

3β-hydroxy-16ξ-phenylsulfinyl-5β-androstan-17-one

Refernces