2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID
• CAS No.: 7356-52-7
• Molecular Formula: C10H10N2O5
• Molecular Weight: 238.2
• Hs Code.: 2924299090
• Mol file: 7356-52-7.mol

Synonyms:2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID

Chemical Property of 2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.15E-10mmHg at 25°C
• Boiling Point: 489.4°C at 760 mmHg
• Flash Point: 249.8°C
• PSA: 112.22000
• Density: 1.459g/cm³
• LogP: 2.15600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Acetamido-4-methyl-2-nitrobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID

There total 4 articles about 2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-acetylamino-4-methylbenzoic acid (6946-14-1) → 3-acetylamino-4-methyl-2-nitrobenzoic acid (7356-52-7)

Guidance literature:

With nitric acid; In water; for 2.5h;

Reference yield: 71.0%

3-acetylamino-4-methylbenzoic acid (6946-14-1) → 5-Acetamino-2-nitro-p-toluolsaeure (6632-23-1) + 3-acetylamino-4-methyl-2-nitrobenzoic acid (7356-52-7)

Guidance literature:

With nitric acid; at 0 ℃;

DOI:10.1016/S0040-4020(00)00803-6

Reference yield:

3-amino-p-toluic acid (2458-12-0) → 3-acetylamino-4-methyl-2-nitrobenzoic acid (7356-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / acetic acid

2: 71 percent / HNO₃ / 0 °C

With nitric acid; In acetic acid; 1: Acetylation / 2: Nitration;

DOI:10.1016/S0040-4020(00)00803-6

upstream raw materials:

3-acetylamino-4-methylbenzoic acid

3-amino-p-toluic acid

Downstream raw materials:

3-amino-4-methyl-2-nitrobenzoic acid

3-bromo-4-methyl-2-nitrobenzoic acid

methyl 3-bromo-4-methyl-2-nitrobenzoate

2-amino-3-bromo-4-methylbenzoic acid

Refernces

• 1、 -. "CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS". . . Retrieved 2015/03/13.
• 2、 -. "SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS". Page/Page column 27; 87. . Retrieved 2008/06/13.