4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one

Base Information

• Chemical Name: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one
• CAS No.: 16352-77-5
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.364
• Mol file: 16352-77-5.mol

Synonyms:4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one

Chemical Property of 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one

There total 3 articles about 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-(4-methylbenzoyl)glycine (27115-50-0) + 4-dimethylamino-benzaldehyde (100-10-7) → 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one (16352-77-5)

Guidance literature:

With sodium acetate; acetic anhydride; at 110 ℃; for 1h; Molecular sieve;

DOI:10.1002/jccs.201500111

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one (16352-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane / 1 h

2: sodium acetate; acetic anhydride / 1 h / 110 °C / Molecular sieve

With sodium acetate; acetic anhydride; sodium hydroxide; In dichloromethane;

DOI:10.1002/jccs.201500111

Reference yield:

p-Toluic acid (99-94-5) → 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one (16352-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 4 h / Reflux

2: sodium hydroxide / dichloromethane / 1 h

3: sodium acetate; acetic anhydride / 1 h / 110 °C / Molecular sieve

With thionyl chloride; sodium acetate; acetic anhydride; sodium hydroxide; In dichloromethane;

DOI:10.1002/jccs.201500111

upstream raw materials:

N-(4-methylbenzoyl)glycine

4-dimethylamino-benzaldehyde

4-methyl-benzoyl chloride

p-Toluic acid

Refernces