5-FLUOROPHTALIC ACID

Base Information

• Chemical Name: 5-FLUOROPHTALIC ACID
• CAS No.: 1583-66-0
• Molecular Formula: C8H5FO4
• Molecular Weight: 184.124
• Hs Code.: 2917399090
• Mol file: 1583-66-0.mol

Synonyms:5-FLUORO-ISOPHTHALIC ACID;5-FLUOROPHTALIC ACID;Nsc302311;5-Fluorobenzene-1,3-dicarboxylic acid

Chemical Property of 5-FLUOROPHTALIC ACID

Chemical Property:

• Vapor Pressure: 2.23E-07mmHg at 25°C
• Melting Point: 295-297℃
• Refractive Index: 1.59
• Boiling Point: 407.7 °C at 760 mmHg
• PKA: 3.19±0.10(Predicted)
• Flash Point: 200.4 °C
• PSA: 74.60000
• Density: 1.551 g/cm³
• LogP: 1.22210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-FluoroisophthalicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoroisophthalic Acid is a useful research chemical.

Technology Process of 5-FLUOROPHTALIC ACID

There total 5 articles about 5-FLUOROPHTALIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-5-methylbenzoic acid (518070-19-4) → 5-fluoroisophthalic acid (1583-66-0)

Guidance literature:

3-fluoro-5-methylbenzoic acid; With potassium permanganate; In water; for 12h; Heating / reflux;

With hydrogenchloride; In water; at 25 ℃;

Reference yield: 14.0%

3,5-dimethylfluorobenzene (461-97-2) → 5-fluoroisophthalic acid (1583-66-0)

Guidance literature:

3,5-dimethylfluorobenzene; With pyridine; potassium permanganate; In water; for 7h; Heating / reflux;

With hydrogenchloride; In water; pH=3;

Reference yield:

3,5-dimethylaminoaniline (108-69-0) → 5-fluoroisophthalic acid (1583-66-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 48percent tetrafluoroboric acid, sodium nitrite / methanol; H₂O

2: Heating

3: potassium permanganate, potassium carbonate / H₂O / 70 h / Heating

With potassium permanganate; tetrafluoroboric acid; potassium carbonate; sodium nitrite; In methanol; water;

DOI:10.1039/P29840000529

upstream raw materials:

3,5-dimethylfluorobenzene

3,5-dimethylaminoaniline

3-fluoro-5-methylbenzoic acid

Downstream raw materials:

5-fluoroisophthalamide

dimethyl 5-fluoroisophthalate

Refernces

• 1、 -. "CHEMICAL COMPOUNDS". Page/Page column 54. . Retrieved 2008/06/13.
• 2、 -. "Herbicidal method". . . Retrieved 2008/06/13.