Isoxsuprine HCl

Base Information

• Chemical Name: Isoxsuprine HCl
• CAS No.: 579-56-6
• Molecular Formula: C18H23NO3^.HCl
• Molecular Weight: 337.846
• Hs Code.: 2922504500
• Mol file: 579-56-6.mol

Synonyms:Isoxsuprine HCl;hydron;4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol;chloride;1048-23-3;9(1H)-Phenanthrenone, 7-(acetyloxy)-2,3,4,4a,10,10a-hexahydro-1,1,4a-trimethyl-8-(1-methylethyl)-, (;AKOS026749865;4-{1-hydroxy-2-[(1-methyl-2-phenoxyethyl)amino]propyl}phenol chlorhydrate

Chemical Property of Isoxsuprine HCl

Chemical Property:

• Vapor Pressure: 3.45E-10mmHg at 25°C
• Melting Point: 203-204°
• Boiling Point: 484.2 °C at 760 mmHg
• PKA: pKa 8.0 (Uncertain);9.8 (Uncertain)
• Flash Point: 246.6 °C
• PSA: 61.72000
• Density: 1.146g/cm3
• LogP: 4.06410
• Storage Temp.: 2-8°C
• Solubility.: Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 337.1444713
• Heavy Atom Count: 23
• Complexity: 299

Purity/Quality:

99%, ^*data from raw suppliers

Isoxsuprine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,N
• Statements: 22-50/53-63-50
• Safety Statements: 36-61-60

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CC(COC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.[Cl-]
• Description: Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties. It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291). Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice. It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 μM). It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.
• Uses: As a vasilodator drug, Isoxsuprine Hydrochloride is used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Isoxsuprine Hydrochloride has been shown to be a β-adrenoreceptor antagonist with β-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. Studies suggest that Isoxsuprine Hydrochloride may be useful as a as a tocolytic agent in the treatment of preterm labour. vasodilator antiepileptic It is prescribed for the symptomatic relief of cerebrovascular insufficiency and improvement of circulation
• Therapeutic Function: Vasodilator

Technology Process of Isoxsuprine HCl

There total 1 articles about Isoxsuprine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ isoxsuprine hydrochloride (579-56-6)

Guidance literature:

Reference yield: 45.0%

copper(II) acetate monohydrate (6046-93-1) + isoxsuprine hydrochloride (579-56-6) → [Cu(isoxsuprine)Cl2]

Guidance literature:

isoxsuprine hydrochloride; With sodium hydroxide; In methanol; for 0.166667h;

copper(II) acetate monohydrate; In methanol; at 20 ℃; for 12h;

DOI:10.1016/j.poly.2019.01.052

Reference yield:

3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone (87-88-7) + isoxsuprine hydrochloride (579-56-6) → C6H4Cl2O4(1-)*C18H23NO3(1+)

Guidance literature:

In 1,4-dioxane;

Refernces