C₂₁H₂₉N₃O₄

Base Information

• Chemical Name: C₂₁H₂₉N₃O₄
• CAS No.: 1379541-13-5
• Molecular Formula: C₂₁H₂₉N₃O₄
• Molecular Weight: 387.479
• Mol file: 1379541-13-5.mol

Synonyms:C₂₁H₂₉N₃O₄

Chemical Property of C₂₁H₂₉N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₉N₃O₄

There total 1 articles about C₂₁H₂₉N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride (79200-57-0) → C21H29N3O4 (1379541-13-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / acetone / 3 h / 20 °C

1.2: pH 7

2.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methylamine / tetrahydrofuran / 6.5 h / 20 - 50 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / acetonitrile / 4 h / 65 °C

6.1: cyclohexa-1,4-diene; ethanol / palladium 10% on activated carbon / 2 h / 85 °C / Reflux

With ethanol; cyclohexa-1,4-diene; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

Reference yield:

C21H29N3O4 (1379541-13-5) → 1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea (1379541-15-7)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

2: acetic acid / 3.25 h / Reflux

3: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

4: methylamine / methanol / 0.83 h / 20 - 65 °C

5: triethylamine / dichloromethane / 1 h / 20 °C

With ammonium hydroxide; acetic acid; triethylamine; methylamine; In methanol; dichloromethane; water; butan-1-ol;

Reference yield:

C21H29N3O4 (1379541-13-5) → 1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea (1379540-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / butan-1-ol / 2 h / 150 °C / 12929 Torr / Microwave irradiations

2: acetic acid / 3.25 h / Reflux

3: ammonium hydroxide / dichloromethane; water / 3 h / 90 °C / Sealed tube

4: methylamine / methanol / 0.83 h / 20 - 65 °C

5: triethylamine / dichloromethane / 1 h / 20 °C

6: trifluoroacetic acid; water / 1.5 h / 20 °C / Cooling with ice

With ammonium hydroxide; water; acetic acid; triethylamine; methylamine; trifluoroacetic acid; In methanol; dichloromethane; water; butan-1-ol;

upstream raw materials:

(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

Downstream raw materials:

1-(3-((((3aR,4R,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

1-(3-((( (1R,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl)(methyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

Refernces