C₁₇H₁₆N₂

Base Information

• Chemical Name: C₁₇H₁₆N₂
• CAS No.: 1422378-38-8
• Molecular Formula: C₁₇H₁₆N₂
• Molecular Weight: 248.327
• Mol file: 1422378-38-8.mol

Synonyms:C₁₇H₁₆N₂

Chemical Property of C₁₇H₁₆N₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆N₂

There total 4 articles about C₁₇H₁₆N₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ C17H16N2 (1422378-38-8)

Guidance literature:

With lithium hydride; In toluene; at 110 ℃; for 12h; Inert atmosphere;

Reference yield: 79.0%

6-methyl-8-bromoquinoline (84839-95-2) + p-toluidine (106-49-0,12221-03-3) → C17H16N2 (1422378-38-8)

Guidance literature:

With palladium diacetate; sodium tert-pentoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120 ℃; for 24h; Glovebox; Inert atmosphere;

DOI:10.1021/ja311682c

Reference yield:

2-bromo-p-toluidine (583-68-6) → C17H16N2 (1422378-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; sulfuric acid / 1.05 h / 0 - 140 °C / Schlenk technique

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium tert-pentoxide / toluene / 24 h / 120 °C / Glovebox; Inert atmosphere

With sulfuric acid; palladium diacetate; sodium tert-pentoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium iodide; In toluene;

DOI:10.1021/ja311682c

upstream raw materials:

2-bromo-p-toluidine

p-toluidine

6-methyl-8-bromoquinoline

Downstream raw materials:

C₁₇H₁₅BrN₂

Refernces

• 1、 -. "Method for synthesis of quinoline-8-amine and derivatives thereof from fluoroquinolines". Page/Page column 5; 11. . Retrieved 2018/02/28.