5α-Chloro-3β,17α-dihydroxypregnan-20-one

Base Information

• Chemical Name: 5α-Chloro-3β,17α-dihydroxypregnan-20-one
• CAS No.: 83914-31-2
• Molecular Formula: C₂₁H₃₃ClO₃
• Molecular Weight: 368.944
• Mol file: 83914-31-2.mol

Synonyms:5α-Chloro-3β,17α-dihydroxypregnan-20-one

Chemical Property of 5α-Chloro-3β,17α-dihydroxypregnan-20-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5α-Chloro-3β,17α-dihydroxypregnan-20-one

There total 1 articles about 5α-Chloro-3β,17α-dihydroxypregnan-20-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(20S)-5α-Chloro-3β-hydroxypregnane-20-carboxaldehyde (83914-30-1) → 17-Hydroxypregnenolone (387-79-1) + 5α-Chloro-3β,17α-dihydroxypregnan-20-one (83914-31-2)

Guidance literature:

With potassium tert-butylate; oxygen; phosphorous acid trimethyl ester; Yield given. Multistep reaction. Title compound not separated from byproducts; 1) tBuOH, DMF, -25 deg C, 3.5 h; 2) acetic acid, THF, 1 h, ice-cooling; 40 h, room temp.;

Reference yield:

5α-Chloro-3β,17α-dihydroxypregnan-20-one (83914-31-2) → 17-hydroxyprogesterone (68-96-2)

Guidance literature:

With pyridine; chromium(VI) oxide; anschliessend mit wss.NaOH;

DOI:10.1021/ja01559a061

upstream raw materials:

(20S)-5α-Chloro-3β-hydroxypregnane-20-carboxaldehyde

Downstream raw materials:

17-hydroxyprogesterone

Refernces