2-fluoroethanesulfonyl chloride

Base Information

• Chemical Name: 2-fluoroethanesulfonyl chloride
• CAS No.: 762-68-5
• Molecular Formula: C2H4ClFO2S
• Molecular Weight: 146.57
• Mol file: 762-68-5.mol

Synonyms:2-fluoroethane-1-sulfonyl chloride;2-Fluor-aethansulfonylchlorid;Ethanesulfonyl chloride,2-fluoro;2-Fluoroethanesulphonyl chloride;2-fluoro-ethanesulfonyl chloride;

Chemical Property of 2-fluoroethanesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.756mmHg at 25°C
• Boiling Point: 190.3°C at 760 mmHg
• Flash Point: 68.9°C
• PSA: 42.52000
• Density: 1.474g/cm³
• LogP: 1.60530

Purity/Quality:

2-fluoroethane-1-sulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoroethanesulfonyl chloride

There total 6 articles about 2-fluoroethanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

thioacetic acid-2-fluoroethyl ester (462-31-7) → 2-fluoroethanesulfonyl chloride (762-68-5)

Guidance literature:

With chlorine; In dichloromethane; water; at 0 ℃;

Reference yield: 56.0%

2-(2-Fluoro-ethylsulfanyl)-2-methyl-propane → 2-fluoroethanesulfonyl chloride (762-68-5)

Guidance literature:

With chlorine; In water; at -5 - 0 ℃;

DOI:10.1021/je00025a039

Reference yield:

benzyl(2-fluoroethyl)sulfane (162308-79-4) → 2-fluoroethanesulfonyl chloride (762-68-5) + benzyl chloride (100-44-7)

Guidance literature:

With chlorine; In water; at -5 - 0 ℃; Title compound not separated from byproducts;

DOI:10.1021/je00025a039

upstream raw materials:

fluoro-2 ethylthiocyanate

benzyl(2-fluoroethyl)sulfane

water

chlorine

Downstream raw materials:

2-fluoro-N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(tetrahydrofuran-3-yloxy)phenyl]ethanesulfonamide

N-[4-(4-cyanophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-fluoroethanesulfonamide

2-fluoro-ethanesulfonyl fluoride

ethylenesulfonyl fluoride

Refernces

• 1、 Bunyagidj,Piotrowska,Aldridge. "SYNTHESIS OF THREE PARTIALLY FLUORINATED ALKANESULFONIC ACIDS AS POTENTIAL FUEL-CELL ELECTROLYTES.". . p. 344 - 346. Retrieved 2007/10/02.