N-chloro-2-fluorobenzamide

Base Information

• Chemical Name: N-chloro-2-fluorobenzamide
• CAS No.: 446-23-1
• Molecular Formula: C₇H₅ClFNO
• Molecular Weight: 173.574
• Mol file: 446-23-1.mol

Synonyms:N-chloro-2-fluorobenzamide

Chemical Property of N-chloro-2-fluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-chloro-2-fluorobenzamide

There total 2 articles about N-chloro-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-fluorobenzamide (445-28-3) → N-chloro-2-fluorobenzamide (446-23-1)

Guidance literature:

With trichloroisocyanuric acid; In methanol; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02632

Reference yield:

2-Fluorobenzoyl chloride (393-52-2) → N-chloro-2-fluorobenzamide (446-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous ammonia

2: aqueous sodium hypochlorite / Behandeln der Reaktionsloesung mit wss. Schwefelsaeure

With ammonium hydroxide; sodium hypochlorite;

Reference yield: 76.0%

N-chloro-2-fluorobenzamide (446-23-1) + diphenyl acetylene (501-65-5) → 8-fluoro-3,4-diphenylisoquinolin-1(2H)-one (1616088-62-0)

Guidance literature:

With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; potassium acetate; silver(I) acetate; In 2,2,2-trifluoroethanol; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02632

upstream raw materials:

2-fluorobenzamide

2-Fluorobenzoyl chloride

Downstream raw materials:

2-Fluoroaniline

8-fluoro-3,4-diphenylisoquinolin-1(2H)-one

Refernces