Technology Process of 1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol
There total 11 articles about 1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: SO2Cl2 / CHCl3
1.2: HBr3*pyriidne
2.1: 3 percent / methanol; pyridine / Electrochemical reaction
3.1: 79 percent / Zn*AcOH / tetrahydrofuran
4.1: 100 percent / Huenig base / CH2Cl2
5.1: 100 percent / K2CO3 / methanol
6.1: 100 percent / imidazole
7.1: B(OMe)3; n-BuLi
7.2: 82 percent / aq. NaOH; H2O2
8.1: 100 percent / K2CO3 / dimethylformamide
9.1: 84 percent / HCO2NH4 / Pd/C / ethanol / 60 °C
10.1: 100 percent / TBAF / tetrahydrofuran
11.1: 81 percent / CH2Cl2
12.1: 27 percent / n-BuLi / tetrahydrofuran
With
1H-imidazole; n-butyllithium; sulfuryl dichloride; Trimethyl borate; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
11.1: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2004.02.154
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 3 percent / methanol; pyridine / Electrochemical reaction
2.1: 79 percent / Zn*AcOH / tetrahydrofuran
3.1: 100 percent / Huenig base / CH2Cl2
4.1: 100 percent / K2CO3 / methanol
5.1: 100 percent / imidazole
6.1: B(OMe)3; n-BuLi
6.2: 82 percent / aq. NaOH; H2O2
7.1: 100 percent / K2CO3 / dimethylformamide
8.1: 84 percent / HCO2NH4 / Pd/C / ethanol / 60 °C
9.1: 100 percent / TBAF / tetrahydrofuran
10.1: 81 percent / CH2Cl2
11.1: 27 percent / n-BuLi / tetrahydrofuran
With
1H-imidazole; n-butyllithium; Trimethyl borate; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
10.1: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2004.02.154