Lomefloxacin hydrochloride

Base Information

• Chemical Name: Lomefloxacin hydrochloride
• CAS No.: 98079-52-8
• Molecular Formula: C₁₇H₁₉F₂N₃O₃*ClH
• Molecular Weight: 387.814
• Hs Code.: 29339900
• European Community (EC) Number: 627-337-1
• NSC Number: 758168
• UNII: 9VC7S3ZXXB
• DSSTox Substance ID: DTXSID2045527
• Wikidata: Q27107226
• NCI Thesaurus Code: C47587
• Metabolomics Workbench ID: 53260
• ChEMBL ID: CHEMBL1728
• Mol file: 98079-52-8.mol

Synonyms:1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;Décalogiflox;Logiflox;lomefloxacin;lomefloxacin hydrochloride;lomenfloxacin;Maxaquin;NY 198;NY-198;Ocacin;Okacin;Okacyn;SC 4711;SC-4711

Chemical Property of Lomefloxacin hydrochloride

Chemical Property:

• Appearance/Colour: White powder with no smell, bitter taste
• Vapor Pressure: 1.31E-12mmHg at 25°C
• Melting Point: 290-300 °C
• Boiling Point: 542.7 °C at 760 mmHg
• Flash Point: 282 °C
• PSA: 74.57000
• LogP: 2.99170
• Storage Temp.: −20°C
• Solubility.: 1 M NaOH: soluble50mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 387.1161255
• Heavy Atom Count: 26
• Complexity: 586

Purity/Quality:

98%min ^*data from raw suppliers

Lomefloxacin, hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
• Description: Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment. Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

Technology Process of Lomefloxacin hydrochloride

There total 1 articles about Lomefloxacin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

lomefloxacin hydrochloride ethyl ester → Lomefloxacin hydrochloride (98079-51-7,98079-52-8)

Guidance literature:

With sulfuric acid; acetic acid; In water; for 2h;

Refernces