N-(m-Hydroxyphenyl)-p-toluenesulphonamide

Base Information

• Chemical Name: N-(m-Hydroxyphenyl)-p-toluenesulphonamide
• CAS No.: 3743-29-1
• Molecular Formula: C13H13 N O3 S
• Molecular Weight: 263.317
• Hs Code.: 2935009090
• European Community (EC) Number: 223-135-9
• DSSTox Substance ID: DTXSID80190877
• Nikkaji Number: J217.639D
• Wikidata: Q83063337
• Mol file: 3743-29-1.mol

Synonyms:3743-29-1;n-(3-hydroxyphenyl)-4-methylbenzenesulfonamide;N-(m-Hydroxyphenyl)-p-toluenesulphonamide;N-(3-hydroxyphenyl)-4-methylbenzene-1-sulfonamide;EINECS 223-135-9;Oprea1_667358;SCHEMBL3259544;DTXSID80190877;MFCD00708551;AKOS002963174;n-(3-hydroxyphenyl)-p-toluenesulfonamide;AS-48246;CS-0309343;EN300-176757;F20611;AE-848/00888035

Chemical Property of N-(m-Hydroxyphenyl)-p-toluenesulphonamide

Chemical Property:

• Melting Point: 158 °C
• Boiling Point: 446.9°Cat760mmHg
• PKA: 8.06±0.10(Predicted)
• Flash Point: 224°C
• PSA: 74.78000
• Density: 1.362g/cm³
• LogP: 3.65520
• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 263.06161445
• Heavy Atom Count: 18
• Complexity: 355

Purity/Quality:

98%Min ^*data from raw suppliers

N-(3-Hydroxyphenyl)-4-methylbenzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=CC=C2)O

Technology Process of N-(m-Hydroxyphenyl)-p-toluenesulphonamide

There total 3 articles about N-(m-Hydroxyphenyl)-p-toluenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

p-toluenesulfonyl chloride (98-59-9) + m-Hydroxyaniline (591-27-5) → N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide (3743-29-1)

Guidance literature:

With pyridine; at 0 ℃; for 1h;

DOI:10.1021/ja300475k

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide (3743-29-1)

Guidance literature:

With m-Hydroxyaniline; In pyridine; for 3.5h; Ice bath;

Reference yield:

ethanol (64-17-5) + p-toluenesulfonyl chloride (98-59-9) + m-Hydroxyaniline (591-27-5) → N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide (3743-29-1)

Guidance literature:

upstream raw materials:

ethanol

p-toluenesulfonyl chloride

m-Hydroxyaniline

Downstream raw materials:

toluene-4-sulfonamide

C₃₄H₄₉NO₇Si

C₂₈H₃₃NO₄

C₁₉H₁₉NO₅S

Refernces

• 1、 -. "Quintuple stimuli-responsive nano-carrier with imaging function and preparation method of quintuple stimuli-responsive nano-carrier". Paragraph 0041; 0049-0050; 0069; 0077-0078. . Retrieved 2019/12/25.
• 2、 Lin, Qiuning,Bao, Chunyan,Cheng, Shuiyu,Yang, Yunlong,Ji, Wei,Zhu, Linyong. "Target-activated coumarin phototriggers specifically switch on fluorescence and photocleavage upon bonding to thiol-bearing protein". supporting information; experimental part. p. 5052 - 5055. Retrieved 2012/05/07.