Nilvadipine

Base Information Edit

Chemical Name:Nilvadipine
CAS No.:75530-68-6
Molecular Formula:C19H19N3O6
Molecular Weight:385.376
Hs Code.:
European Community (EC) Number:805-887-5
UNII:0214FUT37J
DSSTox Substance ID:DTXSID2046624
Nikkaji Number:J22.253D
Wikipedia:Nilvadipine
Wikidata:Q7037489
NCI Thesaurus Code:C84019
Pharos Ligand ID:YQDCZB1AK8FJ
Metabolomics Workbench ID:43691
ChEMBL ID:CHEMBL517427
Mol file:75530-68-6.mol

Synonyms:5-isopropyl-3-methyl-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinecarboxylate;Escor;FR 34235;FR-34235;nilvadipine;Nivadil

Suppliers and Price of Nilvadipine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Nilvadipine
50mg
$ 403.00

TRC
Nilvadipine
50mg
$ 110.00

TCI Chemical
Nilvadipine >95.0%(N)
5g
$ 280.00

TCI Chemical
Nilvadipine >95.0%(N)
1g
$ 94.00

Sigma-Aldrich
Nilvadipine ≥98% (HPLC)
10mg
$ 48.80

Sigma-Aldrich
Nilvadipine ≥98% (HPLC)
50mg
$ 137.00

Medical Isotopes, Inc.
Nilvadipine
50 mg
$ 510.00

CSNpharm
Nilvadipine
10mg
$ 30.00

CSNpharm
Nilvadipine
100mg
$ 47.00

CSNpharm
Nilvadipine
1g
$ 65.00

Total 82 raw suppliers

Chemical Property of Nilvadipine Edit

Chemical Property:

Appearance/Colour:yellow prisms
Vapor Pressure:6.94E-11mmHg at 25°C
Melting Point:148-150 °C
Refractive Index:1.568
Boiling Point:526.7 °C at 760 mmHg
Flash Point:272.3 °C
PSA：134.24000
Density:1.32 g/cm³
LogP:3.30988
Storage Temp.:-20°C Freezer
Solubility.:DMSO: soluble15mg/mL, clear
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:385.12738533
Heavy Atom Count:28
Complexity:783

Purity/Quality:

99% ^*data from raw suppliers

Nilvadipine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
Recent ClinicalTrials:A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease
Recent EU Clinical Trials:A European multicenre double-blind placebo controlled phase III trial of nilvadipine in mild to moderate Alzheimer's disease.
Recent NIPH Clinical Trials:Effects of nilvadipine on the progression of visual field defects in patients with retinitis pigmentosa
Description Nilvadipine is a new, second-generation calcium channel blocker effective in the treatment of hypertension and angina pectoris. Its potent inhibitory effect on the stimulated chemotaxis of smooth muscle cells and protective action against calcium deposition suggest that nilvadipine may be useful for preventing and treating atherosclerosis.
Uses Used as an antihypertensive and antianginal. Used as an antihypertensive and antianginal
Therapeutic Function Calcium entry blocker, Antihypertensive

Technology Process of Nilvadipine

There total 14 articles about Nilvadipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 1452166-70-9
isopropyl 2-hydroxyiminomethyl-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

: 75530-68-6,109545-30-4
nilvadipine

Guidance literature:: With acetic anhydride; potassium carbonate; In dimethyl sulfoxide; at 10 - 50 ℃; for 5h;
DOI:10.1016/j.tetlet.2013.11.079