4-chloroestradiol

Base Information

• Chemical Name: 4-chloroestradiol
• CAS No.: 88847-88-5
• Molecular Formula: C18H23 Cl O2
• Molecular Weight: 306.832
• Mol file: 88847-88-5.mol

Synonyms:4-Chloroestradiol

Chemical Property of 4-chloroestradiol

Chemical Property:

• Vapor Pressure: 5.75E-09mmHg at 25°C
• Boiling Point: 452.2°C at 760 mmHg
• Flash Point: 227.3°C
• PSA: 40.46000
• Density: 1.254g/cm³
• LogP: 4.26260

Purity/Quality:

99%min ^*data from raw suppliers

4-Chloroestradiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloroestradiol is used in the determination of estradiol impurity through HPLC. Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs).

Technology Process of 4-chloroestradiol

There total 3 articles about 4-chloroestradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,10β-dichloro-17β-hydroxyestra-1,4-dien-3-one (116382-89-9) → estradiol (50-28-2) + 4-chloro-17β-estradiol (88847-88-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Yields of byproduct given; Ambient temperature;

Reference yield:

2,4,10β-trichloro-17β-hydroxyesra-1,4-dien-3-one (116382-87-7) → estradiol (50-28-2) + 4-chloro-17β-estradiol (88847-88-5) + 2,4-dichloro-17β-estradiol (25940-39-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Yield given. Yields of byproduct given; Ambient temperature;

Reference yield:

estradiol (50-28-2) → 2-chloroestradiol (88847-87-4) + 4-chloro-17β-estradiol (88847-88-5) + 10β-chloro-17β-hydroxy-estra-1,4-dien-3-one (93999-10-1)

Guidance literature:

With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; In N,N-dimethyl-formamide; Product distribution; Ambient temperature; other estrogens;

DOI:10.1016/0039-128X(94)90065-5

upstream raw materials:

estradiol

4,10β-dichloro-17β-hydroxyestra-1,4-dien-3-one

2,4,10β-trichloro-17β-hydroxyesra-1,4-dien-3-one

Refernces

• 1、 Mukawa, Fumikazu. "10&β-Chloro-17&β-hydroxyestra-1,4-dien-3-one and its Related Compounds". . p. 457 - 460. Retrieved 2007/10/02.