Technology Process of diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate
There total 7 articles about diethyl 2-acetamido-2-(4-(benzyloxy)phenethyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-acetylaminomalonic acid diethyl ester;
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 0 ℃;
for 3h;
2-<4-(Benzyloxy)phenyl>ethyl iodide;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
2-acetylaminomalonic acid diethyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 0.75h;
Schlenk technique;
2-<4-(Benzyloxy)phenyl>ethyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 95 ℃;
for 40h;
Schlenk technique;
DOI:10.1039/c8cc05643a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methyl-triphenylphosphonium iodide; sodium hydride / tetrahydrofuran / 20 °C
2.1: borane-THF / 0 - 20 °C
2.2: 0 - 20 °C
3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Schlenk technique
4.2: 40 h / 95 °C / Schlenk technique
With
1H-imidazole; borane-THF; iodine; methyl-triphenylphosphonium iodide; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c8cc05643a
