Nisoldipine

Base Information Edit

Chemical Name:Nisoldipine
CAS No.:63675-72-9
Molecular Formula:C20H24N2O6
Molecular Weight:388.42
Hs Code.:2933399090
European Community (EC) Number:264-407-7
NSC Number:759106
UNII:4I8HAB65SZ
DSSTox Substance ID:DTXSID0023371
Nikkaji Number:J19.554E
Wikipedia:Nisoldipine
Wikidata:Q3342150
NCI Thesaurus Code:C29291
RXCUI:7435
Pharos Ligand ID:QYGYT37C9TRM
Metabolomics Workbench ID:42762
ChEMBL ID:CHEMBL1726,CHEMBL441428,CHEMBL3192341
Mol file:63675-72-9.mol

Synonyms:Bay K 5552;Nisoldipine

Suppliers and Price of Nisoldipine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Nisoldipine
10mg
$ 50.00

TCI Chemical
Nisoldipine >98.0%(HPLC)(N)
5g
$ 265.00

TCI Chemical
Nisoldipine >98.0%(HPLC)(N)
1g
$ 106.00

Sigma-Aldrich
Nisoldipine ≥98% (HPLC)
10mg
$ 70.40

Sigma-Aldrich
Nisoldipine ≥98% (HPLC)
50mg
$ 293.00

Medical Isotopes, Inc.
Nisoldipine-d3
5 mg
$ 1550.00

DC Chemicals
Nisoldipine >98%
1 g
$ 300.00

ChemScene
Nisoldipine 99.20%
1g
$ 116.00

ChemScene
Nisoldipine 99.20%
100mg
$ 50.00

ChemScene
Nisoldipine 99.20%
500mg
$ 70.00

Total 158 raw suppliers

Chemical Property of Nisoldipine Edit

Chemical Property:

Appearance/Colour:light tan crystals
Vapor Pressure:2.95E-10mmHg at 25°C
Melting Point:147-148 °C
Refractive Index:1.544
Boiling Point:503.3 °C at 760 mmHg
PKA:2.67±0.70(Predicted)
Flash Point:258.2 °C
PSA：110.45000
Density:1.205 g/cm³
LogP:4.05380
Storage Temp.:-20°C Freezer
Solubility.:DMSO: >10mg/mL
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:388.16343649
Heavy Atom Count:28
Complexity:704

Purity/Quality:

99% ^*data from raw suppliers

Nisoldipine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Cardiovascular Agents
Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Recent ClinicalTrials:Single-Dose Fed Bioequivalence Study of Nisoldipine Extended-Release Tablets (40 mg; Mylan) and Sular? Extended-Release Tablets (40 mg; First Horizon) in Healthy Volunteers
Description Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
Uses Dihydropyridine calcium channel blocker. Antihypertensive and antianginal urease inhibitor Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
Therapeutic Function Coronary vasodilator

Technology Process of Nisoldipine

There total 7 articles about Nisoldipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%