1,3-benzodioxol-5-ylmethyl benzoate

Base Information

• Chemical Name: 1,3-benzodioxol-5-ylmethyl benzoate
• CAS No.: 5469-06-7
• Molecular Formula: C15H12O4
• Molecular Weight: 256.258
• Mol file: 5469-06-7.mol

Synonyms:

Chemical Property of 1,3-benzodioxol-5-ylmethyl benzoate

Chemical Property:

• Vapor Pressure: 3.24E-06mmHg at 25°C
• Boiling Point: 387.7°C at 760 mmHg
• Flash Point: 172.7°C
• Density: 1.286g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-benzodioxol-5-ylmethyl benzoate

There total 7 articles about 1,3-benzodioxol-5-ylmethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

bromobenzene (108-86-1,52753-63-6) + benzo[d][1,3]dioxol-5-ylmethyl formate (85262-96-0) → benzo[d][1,3]dioxol-5-ylmethyl benzoate (5469-06-7)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; In o-xylene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201900700

Reference yield: 80.0%

piperonol (495-76-1) + benzoyl chloride (98-88-4) → benzo[d][1,3]dioxol-5-ylmethyl benzoate (5469-06-7)

Guidance literature:

With lithium perchlorate; In tetrahydrofuran; at 25 ℃; for 7h;

DOI:10.1055/s-2002-25345

Reference yield: 77.0%

piperonol (495-76-1) + N-benzyl-N-(tert-butoxycarbonyl)-benzamide (85909-02-0) → benzo[d][1,3]dioxol-5-ylmethyl benzoate (5469-06-7)

Guidance literature:

With sodium t-butanolate; In toluene; at 150 ℃; for 24h; Sealed tube;

DOI:10.1007/s11426-020-9883-3

upstream raw materials:

piperonol

benzoyl chloride

benzoic acid

bromobenzene

Refernces

• 1、 Lai, Ming,Qi, Xinxin,Wu, Xiao-Feng. "Palladium-Catalyzed Carbonylative Synthesis of Benzyl Benzoates Employing Benzyl Formates as Both CO Surrogates and Benzyl Alcohol Sources". supporting information. p. 3776 - 3778. Retrieved 2019/06/24.
• 2、 Wybon, Clarence C. D.,Mensch, Carl,Hollanders, Charlie,Gadais, Charlène,Herrebout, Wouter A.,Ballet, Steven,Maes, Bert U. W.. "Zn-Catalyzed tert-Butyl Nicotinate-Directed Amide Cleavage as a Biomimic of Metallo-Exopeptidase Activity". . p. 203 - 218. Retrieved 2018/01/17.