Technology Process of 1-tert-butyl 2-ethyl (2S,4R)-4-cyclohexyl-5-oxo-1,2-pyrrolidinedicarboxylate
There total 3 articles about 1-tert-butyl 2-ethyl (2S,4R)-4-cyclohexyl-5-oxo-1,2-pyrrolidinedicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-tert-butyl 2-ethyl (2S)-4-(1-hydroxycyclohexyl)-5-oxo-1,2-pyrrolidinedicarboxylate;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 48h;
With
hydrogen;
platinum(IV) oxide;
In
ethyl acetate;
at 20 ℃;
for 18h;
Further stages.;
atmospheric pressure;
DOI:10.1016/j.bmc.2007.01.033
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C
1.2: 80 percent / BF3*OEt2 / tetrahydrofuran / 2.5 h / -78 °C
2.1: methanesulfonyl chloride; triethylamine / CH2Cl2 / 48 h / 20 °C
2.2: 527 mg / hydrogen / platinum(IV) oxide / ethyl acetate / 18 h / 20 °C / atmospheric pressure
With
methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2007.01.033
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C
1.2: 80 percent / BF3*OEt2 / tetrahydrofuran / 2.5 h / -78 °C
2.1: methanesulfonyl chloride; triethylamine / CH2Cl2 / 48 h / 20 °C
2.2: 527 mg / hydrogen / platinum(IV) oxide / ethyl acetate / 18 h / 20 °C / atmospheric pressure
With
methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2007.01.033