Biperiden

Base Information

• Chemical Name: Biperiden
• CAS No.: 514-65-8
• Molecular Formula: C21H29NO
• Molecular Weight: 311.467
• Hs Code.: 2933399090
• European Community (EC) Number: 208-184-6
• NSC Number: 759145
• UNII: 0FRP6G56LD
• DSSTox Substance ID: DTXSID6022680
• Nikkaji Number: J2.059A
• Wikipedia: Biperiden
• Wikidata: Q414914
• NCI Thesaurus Code: C65263
• Pharos Ligand ID: 9PF6YG1SK2YB
• Metabolomics Workbench ID: 43101
• ChEMBL ID: CHEMBL1101
• Mol file: 514-65-8.mol

Synonyms:Akineton;alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol;Biperiden;Biperiden Hydrochloride;Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer;Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer;Biperidene;Hydrochloride, Biperiden

Chemical Property of Biperiden

Chemical Property:

• Vapor Pressure: 4.14E-09mmHg at 25°C
• Melting Point: 114 °C
• Refractive Index: 1.595
• Boiling Point: 462.1 °C at 760 mmHg
• PKA: 14.05±0.29(Predicted)
• Flash Point: 224.5 °C
• PSA: 23.47000
• Density: 1.105 g/cm³
• LogP: 3.90030
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly,Sonicated), Methanol (Slightly, Sonicated)
• Water Solubility.: 25.1 mg/L
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 311.224914549
• Heavy Atom Count: 23
• Complexity: 422

Purity/Quality:

99% ^*data from raw suppliers

Biperiden ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Antiparkinson Agents
• Canonical SMILES: C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O
• Recent ClinicalTrials: Use of Biperiden for the Prevention of Post-traumatic Epilepsy
• Recent EU Clinical Trials: Estudio de la eficacia de la cafeína en el tratamiento de mantenimiento de pacientes con dependencia de cocaína
• Recent NIPH Clinical Trials: Antipsychotic dose increase or stay in non-responders with schizophrenia: A double-blind randomized controlled trial
• Uses: amoebicide
• Therapeutic Function: Antiparkinsonian
• Clinical Use: Biperiden is used in all types of Parkinson disease (postencephalitic,idiopathic, arteriosclerotic) and helps toeliminate akinesia, rigidity, and tremor. It is also usedin drug-induced extrapyramidal disorders to eliminatesymptoms and permit continued use of tranquilizers.Biperiden is also of value in spastic disorders not related toparkinsonism, such as multiple sclerosis, spinal cord injury,and cerebral palsy. It is contraindicated in all formsof epilepsy.

Technology Process of Biperiden

There total 1 articles about Biperiden which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ biperiden (514-65-8,163296-11-5)

Guidance literature:

Refernces

• 1、 -. "Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins". . . Retrieved 2008/06/13.