2-Chloro-4-hydroxypyridine

Base Information

• Chemical Name: 2-Chloro-4-hydroxypyridine
• CAS No.: 17228-67-0
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.546
• Hs Code.: 2933399090
• European Community (EC) Number: 241-399-3
• DSSTox Substance ID: DTXSID00938117
• Nikkaji Number: J287.026F,J318.182K
• Wikidata: Q72458797
• Mol file: 17228-67-0.mol

Synonyms:2-Chloro-4-hydroxypyridine;17368-12-6;2-Chloropyridin-4-ol;2-chloro-1H-pyridin-4-one;4-Pyridinol, 2-chloro-;2-Chloro-4-pyridinol;4(1H)-Pyridinone, 2-chloro-;2-Chloropyridin-4(1H)-one;MFCD01646108;EINECS 241-399-3;2-chlorpyridin-4-ol;4-Pyridinol, 2-chloro;4-hydroxy-2-chloropyridine;2-chloro-4-hydroxy pyridine;2-chloro-4-hydroxy-pyridine;SCHEMBL106583;DTXSID00938117;CS-D1163;EINECS 241-265-4;AB6909;BBL103172;CL0074;MFCD00955631;STL556982;AKOS005064138;AKOS025395586;AB09576;AC-3372;PS-5596;SB16051;2-chloro-4-hydroxypyridine, AldrichCPR;SY006501;AM20050879;C2516;CS-0166782;FT-0601336;FT-0660623;EN300-90616;A811552;AC-907/34115048;J-508778;J-512337;W-111729

Chemical Property of 2-Chloro-4-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.0879mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 225.1 °C at 760 mmHg
• Flash Point: 89.9 °C
• PSA: 32.86000
• Density: 1.35 g/cm³
• LogP: 1.02830
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 128.9981414
• Heavy Atom Count: 8
• Complexity: 171

Purity/Quality:

99%min ^*data from raw suppliers

2-Chloro-4-pyridone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=CC1=O)Cl

Technology Process of 2-Chloro-4-hydroxypyridine

There total 2 articles about 2-Chloro-4-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloropyridin-4-ol (17368-12-6) → 2-chloropyridin-4(1H)-one (17228-67-0)

Guidance literature:

In methanol; Thermodynamic data; Free energy difference between protomers; other solvents;

DOI:10.1021/jo01296a001

Reference yield:

→ 2-chloropyridin-4(1H)-one (17228-67-0)

Guidance literature:

2-Chlor-4-nitropyridin, Hydrolyse;

DOI:10.1021/ja00455a037

Reference yield: 87.0%

2-chloropyridin-4(1H)-one (17228-67-0) + Cyclohexylmethyl bromide (2550-36-9) → 4-(methylcyclohexyloxy)-2-chloropyridine

Guidance literature:

2-chloropyridin-4(1H)-one; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h; Inert atmosphere;

Cyclohexylmethyl bromide; In N,N-dimethyl-formamide; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c7dt04201a

upstream raw materials:

2-chloropyridin-4-ol

Downstream raw materials:

2-chloropyridin-4-ol

2-chloro-4-(phenyl)pyridine

Refernces

• 1、 Beak, Peter,Covington, Johnny B.,White, J. Matthew. "Quantitative Model of Solvent Effects on Hydroxypyridine-Pyridone and Mercaptopyridine-Thiopyridone Equilibria: Correlation with Reaction-Field and Hydrogen-Bonding Effects". . p. 1347 - 1353. Retrieved 2007/10/02.