2-(4-Biphenylyl)-2-propanol

Base Information

• Chemical Name: 2-(4-Biphenylyl)-2-propanol
• CAS No.: 34352-74-4
• Deprecated CAS: 13860-22-5
• Molecular Formula: C15H16O
• Molecular Weight: 212.291
• Hs Code.: 2906299090
• European Community (EC) Number: 251-955-7
• UNII: 6JKX84G2QQ
• DSSTox Substance ID: DTXSID6067834
• Nikkaji Number: J287.911E
• Wikidata: Q81994491
• Mol file: 34352-74-4.mol

Synonyms:2-(4-Biphenylyl)-2-propanol;34352-74-4;2-(4-phenylphenyl)propan-2-ol;2-([1,1'-Biphenyl]-4-yl)propan-2-ol;2-(biphenyl-4-yl)propan-2-ol;6JKX84G2QQ;2-(4-Biphenyl)-2-propanol;[1,1'-Biphenyl]-4-methanol, .alpha.,.alpha.-dimethyl-;EINECS 251-955-7;2-{[1,1'-BIPHENYL]-4-YL}PROPAN-2-OL;(1,1'-Biphenyl)-4-methanol, alpha,alpha-dimethyl-;alpha,alpha-Dimethyl(1,1'-biphenyl)-4-methanol;alpha,alpha-dimethyl[1,1'-biphenyl]-4-methanol;(1,1'-BIPHENYL)-4-METHANOL, .ALPHA.,.ALPHA.-DIMETHYL-;UNII-6JKX84G2QQ;Cambridge id 5135301;SCHEMBL429422;2-(p-Biphenylyl)-2-propanol;DTXSID6067834;HMS1577L21;MFCD00014390;STK366689;AKOS005443421;2-(4-Biphenylyl)-2-propanol, 95%;2-[1,1'-Biphenyl]-4-yl-2-propanol;AS-62450;CS-0204787;FT-0608585;FT-0608586;EN300-1869758;SR-01000196549;2-(4-Biphenylyl)-2-propanol, >=95.0% (HPLC);J-019565;SR-01000196549-1;.ALPHA.,.ALPHA.-DIMETHYL(1,1'-BIPHENYL)-4-METHANOL

Chemical Property of 2-(4-Biphenylyl)-2-propanol

Chemical Property:

• Melting Point: 88-92 °C
• Boiling Point: 343.2°Cat760mmHg
• PKA: 14.40±0.29(Predicted)
• Flash Point: 143.7°C
• PSA: 20.23000
• Density: 1.048g/cm³
• LogP: 3.58100
• Solubility.: chloroform: soluble1g/10 mL, clear, colorless
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 212.120115130
• Heavy Atom Count: 16
• Complexity: 208

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-Biphenylyl)-2-propanol ≥95.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC=C(C=C1)C2=CC=CC=C2)O

Technology Process of 2-(4-Biphenylyl)-2-propanol

There total 11 articles about 2-(4-Biphenylyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1-biphenyl-4-yl-1-methyl-ethoxy)trimethylsilyl ether (669055-44-1) → 2-biphenyl-4-yl-propan-2-ol (34352-74-4)

Guidance literature:

With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate; at 20 ℃; for 0.0666667h; Green chemistry;

DOI:10.1016/j.molcata.2012.08.002

Reference yield: 95.0%

phenylzinc iodide-lithium chloride complex + 2-(4-iodophenyl)propan-2-ol (60514-82-1) → 2-biphenyl-4-yl-propan-2-ol (34352-74-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo8015852

Reference yield: 95.0%

methyl magnesium iodide (917-64-6) + methyl 4-phenylbenzoate (720-75-2) → 2-biphenyl-4-yl-propan-2-ol (34352-74-4)

Guidance literature:

In diethyl ether; for 5h; Heating;

DOI:10.1021/ja00529a001

upstream raw materials:

biphenyl-4-acetaldehyde

methylmagnesium bromide

methyl magnesium iodide

methyl 4-phenylbenzoate

Downstream raw materials:

3,3-Dimethyl-3H-isobenzofuran-1-one

4-phenylalanine

2-(biphenyl-4-yl)-2-azidopropane

C₃₉H₃₉BrN₂O₈S

Refernces

• 1、 -. "Method for selectively oxidizing cumene compounds". Paragraph 0105; 0106. . Retrieved 2019/11/21.
• 2、 Malekafzali,Malinovska,Patureau. "The cumene/O2 system: A very simple tool for the radical chain oxidation of some functional groups". supporting information. p. 6981 - 6985. Retrieved 2017/08/02.