Iopromide

Base Information

• Chemical Name: Iopromide
• CAS No.: 73334-07-3
• Molecular Formula: C18H24I3N3O8
• Molecular Weight: 791.117
• Hs Code.: 2924296000
• European Community (EC) Number: 277-385-9
• UNII: 712BAC33MZ
• DSSTox Substance ID: DTXSID0023163
• Nikkaji Number: J11.916D
• Wikipedia: Iopromide
• Wikidata: Q4202805
• NCI Thesaurus Code: C1137
• RXCUI: 27781
• Metabolomics Workbench ID: 49618
• ChEMBL ID: CHEMBL1725
• Mol file: 73334-07-3.mol

Synonyms:Clarograf;iopromid;iopromide;lopromid;N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide;Ultravist;Ultravist 300

Chemical Property of Iopromide

Chemical Property:

• Appearance/Colour: off-white to white powder
• Vapor Pressure: 5E-30mmHg at 25°C
• Melting Point: broad (160oC transition)
• Refractive Index: 1.709
• Boiling Point: 840.9 °C at 760 mmHg
• PKA: 10.62±0.70(Predicted)
• Flash Point: 462.4 °C
• PSA: 168.66000
• Density: 2.173 g/cm³
• LogP: 0.05740
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility.: Freely soluble in water and in dimethyl sulfoxide, practically insoluble in ethanol (96 per cent) and in acetone.
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 790.8698
• Heavy Atom Count: 32
• Complexity: 647

Purity/Quality:

99.9% ^*data from raw suppliers

Iopromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I
• Recent ClinicalTrials: Pediatric Risk of Hypothyroidism With Iodinated Contrast Media
• Recent EU Clinical Trials: The role of Contrast-Enhanced Spectral Mammography (CESM) in the diagnostic process of breast cancer: can it improve specificity of first-line examinations and therefore reduce the suspicious lesions that undergo vacuum assisted breast biopsy (VABB)?
• Description: Iopromide is a non-ionic, water-soluble X-ray contrast agent for intravascular administration. Iopromide can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.
• Uses: Contrast molecule

Technology Process of Iopromide

There total 47 articles about Iopromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C26H32I3N3O12 → iopromide (73334-07-3)

Guidance literature:

With sodium methylate; In methanol; at 75 ℃; for 8h;

Reference yield: 95.0%

3-methylamino-propane-1,2-diol (40137-22-2) + 3-[(2,3-dihydroxypropylaminoformyl)]-2,4,6-triiodo-5-[(methoxyacetyl)amino]benzoic acid methyl ester → iopromide (73334-07-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; Large scale;

Reference yield: 92.0%

3-Amino-1,2-propanediol (616-30-8,13552-31-3,98923-21-8) + 5-[(2-methoxy)acetamido]-3-(2,3-dihydroxy-N-propyl(methyl)carbamoyl)-2,4,6-triiodobenzoyl chloride → iopromide (73334-07-3)

Guidance literature:

With sodium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

upstream raw materials:

3-methylamino-propane-1,2-diol

pyrographite

5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

Refernces

• 1、 -. "Preparation method of iopromide". Paragraph 0043; 0052; 0053; 0054; 0063; 0064. . Retrieved 2019/08/01.
• 2、 -. "A method for preparing [...]". . . Retrieved 2018/12/13.